Kule mithi yokugoma emine, imiphumela engcono kakhulu yatholwa nge-PV-1950, ngesikhathi esifanayo eqondise ama-epitopes amathathu e-B cell ale molecule ye-pathological, ebonisa ukuncipha okubaluleke kakhulu kwe-α-Synuclein kanye ne-neurodegeneration ebuchosheni bamagundane omugqa we-hα-Syn D agonyiwe.
UDkt. Agadjanyan uthe, “Ukwakhiwa komgomo ophephile novikela amasosha omzimba oqondiswe kuzo zonke izinhlobo ze-phathological α-Synuclein kuwumgomo we-IMM. Okubalulekile, umgomo wethu osebenza ngempumelelo kakhulu, i-PV-1950, ukhiqize ukukhiqizwa okuqinile kwe-antibody, ukwehlisa i-α-Synuclein ye-pathological kanye nokwenza ngcono ukushoda kwezimoto kumodeli yegundane yesifo usulungele ukuhlolwa ezivivinyweni zokuvikela zokuvikela”. Uqhube wathi, “I-PV-1950 inezinguqulo ezimbili - eyodwa esekelwe ku-DNA kanti enye isekelwe kumaprotheni ahlanganisiwe. Ukugoma okuhambisanayo okune-heterologous DNA kanye nemithi yokugomela amaprotheni kungenye indlela futhi ethembisayo yokuthola izimpendulo ezikhudlwana zama-antibody."
I-PD iyinkinga yesibili evame kakhulu ye-neurodeergenerative yokuguga ethinta kokubili ukusebenza kwezimoto nengqondo. Isikhungo sibheke ekwelashweni okusekelwe emuthini wokugoma wezifo ze-neurodeergenerative ezifana ne-PD, DLB, ne-AD. Umuthi wokugomela i-immunogenic ungaba indlela ephumelela kakhulu yokuvimba/ukuvimbela ukuhlanganiswa kwephrotheni ye-α-Synuclein enobuthi ekuqongeleleni nasekusakazekeni ebuchosheni futhi kumiswe noma kubambezele isifo, kusho i-IMM.
“I-α-Synuclein iyiphrotheni ye-neuronal exhunywe ngokofuzo kanye ne-neuropathologically kuma-α-synucleopathies ahlukahlukene, okuhlanganisa nesifo sika-Parkinson (PD). Uma i-pathology iqala, kuba cishe akunakwenzeka ukuyimisa, ngakho-ke ukusebenzisa umuthi wokugoma osuselwa endaweni ye-MultiTEP ovela ku-IMM Nuravax ufuna ukumisa noma ukubambezela lesi sifo kubantu abasengozini ye-α-synucleopathies,” kusho u-Roman Kniazev.