Ukuhlolwa Okusha Komtholampilo Kokwelashwa Komdlavuza Wendlala Yendlala

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I-Hinova Pharmaceuticals Inc., inkampani yesigaba somtholampilo ye-biopharmaceutical egxile ekuthuthukiseni izindlela zokwelapha ezinomdlavuza nezifo ze-metabolic ngobuchwepheshe obuhlosiwe bokuwohloka kwamaprotheni, imemezele ukuthi isiguli sokuqala esinomdlavuza wendlala yesinye we-metastatic castration-resistant Prostate (mCRPC) sikhishwe ngempumelelo esigabeni I. isilingo somtholampilo se-HP518, i-chimeric degrader ekhethwa kakhulu futhi etholakala ngomlomo eqondise i-androgen receptor (AR). Ucwaningo oluqhubekayo lwelebula evulekile lweSigaba I e-Australia luzohlola ukuphepha, i-pharmacokinetics, nomsebenzi wokulwa nesimila we-HP518 ezigulini ezine-mCRPC.

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I-HP518 itholwe futhi yathuthukiswa inkundla yokutholwa kwezidakamizwa ezihlosiwe ka-Hinova zokucekela phansi amaprotheni. Inamandla okunqoba ukumelana nemithi yomdlavuza wendlala yesinye ngenxa yokuguqulwa okuthile kwe-AR.

I-Chimeric degraders ama-molecule amancane asebenza kabili akhuthaza ukuwohloka kwamaprotheni okuhlosiwe anamandla aphezulu kanye nokukhetha okuphezulu. Lobu buchwepheshe bunamandla okukhomba okuqondiwe okungadakwa futhi bunqobe inkinga yokumelana nezidakamizwa yemithi yendabuko yama-molecule amancane.

"Lesi yingqopha-mlando ebalulekile ekuqhubekeleni phambili kwemizamo yethu kusukela ekutholakaleni kwezidakamizwa kuya ocwaningweni lomtholampilo," kusho u-Yuanwei Chen, Ph.D., uMongameli kanye ne-CEO ye-Hinova. "Sijabule ngakho futhi sizinikele ekuletheni izindlela ezintsha zokwelapha ezigulini emhlabeni wonke!"

Ngenkundla yokutholwa kwezidakamizwa ezihlosiwe zokonakaliswa kwamaprotheni, i-Hinova ingakwazi ukuhlola umsebenzi wokuwohloka kwamaprotheni ngokushesha futhi ifeze ukuklama okuphumelelayo kanye nokwenza ngokugcwele okonakaliswa kwe-chimeric. Ngaphezu kwalokho, u-Hinova unolwazi olujulile ekulawuleni ukukhiqizwa kwamakhemikhali kwe-Chimeric degrader compounds.

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