Ukuhlolwa Okusha Komtholampilo Kuhlola Ukukhuthazwa Kwengqondo Ejulile Ukuze Ukwelapha I-Alzheimer's

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Odokotela be-Allegheny Health Network (AHN) bajoyine isilingo somtholampilo esiyingqopha-mlando esihlola ukuphepha nokusebenza kokwelashwa okujulile kokuvuselela ubuchopho ukwelapha isifo i-Alzheimer's. Iholwa uDonald Whiting, MD, usihlalo we-AHN's Neurosciences Institute, Isikhulu Esiphezulu Sezokwelapha se-AHN, kanye nephayona ekusetshenzisweni kwe-DBS ukwelapha izimo ezihlukahlukene eziwohlozayo zezinzwa, i-ADvance II Study iyisivivinyo somtholampilo sesigaba sesi-3 samazwe ngamazwe esinikezwa kuphela. ezikhungweni zezokwelapha ezikhethiwe emhlabeni wonke.

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"Sazi ngokusebenzisa kwethu i-DBS cishe iminyaka engamashumi amabili ukwelapha ukuphazamiseka kokunyakaza okufana nokundindizela kukaParkinson kanye nokundindizela okubalulekile ukuthi le nqubo iyindlela yokwelapha ephephile futhi ebekezelelwa kahle," kusho uDkt. Whiting. Bangaphezu kuka-160,000 abantu emhlabeni jikelele abathole ukwelashwa kwe-DBS kulezo zimo.

I-AHN ingesinye seziza ezingama-20 kuphela e-United States ezikhethelwe ukubamba iqhaza Ocwaningweni Lwe-ADvance II nalo oluqhutshwa eCanada naseJalimane.

I-Alzheimer's iwuhlobo oluvame kakhulu lokuwohloka komqondo. Balinganiselwa ezigidini ezingu-6.2, noma oyedwa kwabayisishiyagalolunye baseMelika abaneminyaka engu-65 nangaphezulu uphila ne-Alzheimer's; Amaphesenti angu-72 aneminyaka engu-75 noma ngaphezulu. I-Alzheimer's yisifo esiqhubekayo futhi lapho ifika ekupheleni, ama-neurons ezingxenyeni zobuchopho ezenza umuntu akwazi ukwenza imisebenzi eyisisekelo yomzimba, njengokuhamba nokugwinya. Lesi sifo ekugcineni siyabulala futhi alikho ikhambi elaziwayo. 

I-DBS ye-Alzheimer's ihilela ukusetshenziswa komshini otshaliwe ofana nomshini wokushaya inhliziyo nezintambo ezimbili ezinamathiselwe eziletha ama-pulses kagesi athambile ngqo endaweni yobuchopho ebizwa ngokuthi i-fornix (DBS-f), ehlotshaniswa nenkumbulo nokufunda. Ukukhuthazwa kukagesi kukholakala ukuthi kwenza kusebenze ukujikeleza kwenkumbulo ebuchosheni ukuze kucije ukusebenza kwawo.

Ucwaningo olungahleliwe, olungaboni kabili luzothatha iminyaka emine kubahlanganyeli, ngamunye wabo ozohlolwa okujwayelekile kwe-Alzheimer ngaphambi kokuthi kufakwe i-neurostimulator. Imiphumela yalokhu kuhlola ngokomzimba, kwengqondo, nokuqonda izosetshenziswa njengesilinganiso sokuqala njengoba ihlolwa njalo izinga lokuqhubeka kwe-Alzheimer phakathi nesikhathi socwaningo.

Ngemuva kokufakelwa, izingxenye ezimbili kwezintathu zeziguli zizohlelwa ngokungahleliwe ukuze i-neurostimulator yazo isebenze futhi ingxenye eyodwa kwezintathu izobe ishiywe. Iziguli idivayisi yazo evaliwe ekuqaleni kocwaningo zizoyenza isebenze ngemva kwezinyanga eziyi-12.

Kuso sonke isikhathi socwaningo lomtholampilo, ababambiqhaza bocwaningo bazogadwa ithimba lezinhlaka eziningi lodokotela bezinzwa be-AHN, odokotela bengqondo nodokotela abahlinza izinzwa, okuhlanganisa noDkt. Whiting kanye nodokotela ohlinzayo wakwa-AHN kanye nochwepheshe we-DBS u-Nestor Tomycz, MD.

Ukuze zifanelekele lolu cwaningo, iziguli kufanele zibe neminyaka engama-65 noma ngaphezulu, kutholakale ukuthi zine-Alzheimer's emaphakathi, zibe nempilo enhle, futhi zibe nomnakekeli oqokiwe noma ilungu lomndeni elizobaphelezela lapho bevakashela udokotela.

"Imiphumela yezigaba zangaphambili zalolu cwaningo lomtholampilo iyathembisa futhi ikhombisa ukuthi ukwelashwa kungase kuzuze iziguli ezine-Alzheimer's encane ngokuzinzisa kanye nokuthuthukisa ukusebenza kwazo kwengqondo," kusho uDkt. Whiting. “Ukusho ukuthi umphumela oyimpumelelo walolu cwaningo ungashintsha impilo yezigidi zabantu baseMelika abathintwe yilesi sifo esiwohlozayo, esibulalayo asiyona into encane. Sijabule kakhulu ngokuba phakathi kwamaqembu ahlinzayo ahlonishwayo emhlabeni wonke anikeza iziguli ezine-Alzheimer's ukufinyelela kulokhu okuqanjwa kabusha. "

Ngaphansi kobuholi bukaDkt. Whiting, Isibhedlela i-Allegheny General Hospital se-AHN sekuyisikhathi eside sihamba phambili emizamweni yokuphayona yokuqhubekisela phambili ukusetshenziswa kokuvuselela ubuchopho obujulile. Isibhedlela kwaba ngesokuqala entshonalanga ye-Pennsylvania ukusebenzisa ubuchwepheshe ukwelapha ukuzamazama okubalulekile kanye Nesifo sika-Parkinson, futhi muva nje, uDkt. Whiting nethimba lakhe baqale isigaba sesibili sokuhlolwa komtholampilo ukuhlola ukusebenza kahle kwe-DBS ukusiza ukuphatha ukukhuluphala ngokweqile.

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