Ephepheni, Ukusebenza Kwephaneli Yezitho Zangasese Zowesifazane Kuqhathaniswa Nokuxilongwa Komtholampilo Kwe-Vaginitis - ebika okutholwe ocwaningweni lomtholampilo lwe-BD - izimbangela ezintathu ze-vaginitis (i-bacterial vaginosis [BV], i-vulvovaginal candidiasis [VVC] noma i-Trichomonas vaginalis [TV ]) zacwaningwa ukuze kuqhathaniswe ukuhlolwa kodokotela nemiphumela yokuhlolwa kwamangqamuzana. Ucwaningo lwathola ukuthi uma kuqhathaniswa nokuhlolwa kwamangqamuzana, ukuxilongwa komtholampilo kuphuthelwe amaphesenti angu-45.3 wamacala amahle (180 ka-397) futhi kukhombe ngokungalungile amaphesenti angu-12.3 wamacala angalungile njengama-positives (123 ka-879).
Ucwaningo luphinde lwakhethwa ukuze lufakwe ku-Obstetrics & Gynecology Journal Club, ekhetha izifundo ezimbili kuya kwezintathu ngomagazini ngamunye ukuze kunikezwe abafundi bezokwelapha ithuba lokubuyekeza amaphepha ayingqopha-mlando futhi babasize bakhe isisekelo sokwenza okusekelwe ebufakazini.
Phakathi kwezigidi ezingu-6 nezingu-10 ukunakekelwa kwezempilo okuvakashelwa abesifazane base-US kuhlobene nezimpawu ze-vaginitis.1,2 Nakuba i-vaginitis iyisimo esivamile, ukuxilongwa kwezimbangela zayo ezivamile3,4 (BV, VVC, noma i-TV) kwabesifazane bokuzala. iminyaka ayinqunyelwe.
"Ukuxilongwa okungalungile kusho izincomo zokwelashwa ezingalungile - kungaba ukwelashelwa noma ukweqisa," kusho umbhali ohlanganyele wocwaningo uMolly Broache, umxhumanisi wesayensi yezokwelapha we-Integrated Diagnostic Solutions e-BD. “Owesifazane angase acelwe ukuba enze izimpindelo kudokotela okungadingekile, noma angase ahlaselwe yimithi elwa namagciwane ngenxa yokuthi uphuza ama-antibiotic angawadingi ngempela.”
Ucwaningo luqhathanise ukuhlonzwa komtholampilo kwe-vaginitis nemiphumela yokuhlolwa kwephaneli yesitho sangasese sowesifazane okwenziwa ku-BD MAX™ System, ukuhlolwa kwe-molecular egunyaziwe yemakethe ye-FDA esebenzisa i-nucleic acid amplification ukuze kutholwe izimbangela ezincane ze-BV, VVC, ne-TV. Ucwaningo lubandakanya ababambiqhaza abangama-489 ababenezimpawu. Ababambiqhaza bathole ukuxilongwa komtholampilo futhi baba ne-swab yokuhlolwa kwesitho sangasese sowesifazane esiqoqwe ngesikhathi sokuvakasha kwabo. Ama-swabs athunyelwa esikhungweni sokuhlola esihlukile futhi kamuva saqhathaniswa nokuxilongwa komtholampilo.
"Ngempela siyabadela abesifazane uma singasebenzisi amathuluzi angcono kakhulu esinawo ukuze sihlonze imbangela noma izimbangela zezimpawu ezibaqhubele ekutheni bafune usizo lwezempilo," kusho omunye umbhali wocwaningo uBarbara Van Der Pol, Ph.D. ., i-MPH kanye noProfesa Wezokwelapha kanye Nezempilo Yomphakathi. “Izifo eziningi zidalwa yizinto eziphilayo eziningi ukuze sicabange ukuthi singazikhomba ngendlela efanele ngaphandle kokuhlolwa kwezifo ezisezingeni eliphezulu. Imininingwane ekuleli phepha iqinisekisa ukuthi sikweleta abesifazane izinketho ezinhle kakhulu ezitholakalayo futhi ukubonwa komtholampilo akwanele. ”
I-BD MAX™ Vaginal Panel Assay ingasiza ukubhekana nemikhawulo yokuxilongwa komtholampilo futhi ingasiza ekuthuthukiseni ukunemba kokuxilonga. Lokhu kuhlola okuzenzakalelayo kunesikhathi sokushintsha esifushane (cishe amahora amathathu ukusebenza phakathi kwamasampuli amabili nangama-24 ngesikhathi esisodwa), ngakho imiphumela yosuku olufanayo ingenzeka uma udokotela enethuluzi elitholakala esizeni. I-Assay automation iklanyelwe ukunciphisa ukuhlukahluka kanye nokuzithoba, ngaleyo ndlela kusize ukukhulisa ukunemba kokuxilonga.
“Uma owesifazane exilongwa ngendlela engafanele - etshelwa ukuthi akanaso isitho sangasese sowesifazane kodwa empeleni uyakwenza noma utshelwe ukuthi une-vaginitis kodwa akathelelekile - kudala ubunzima nengozi,” kusho uBroache. "Abesifazane bafanelwe okungcono."
LOKHO ONGAKUTHATHE KULESI SIHLOKO:
- In the paper, Performance of a Vaginal Panel Assay Compared With the Clinical Diagnosis of Vaginitis — which reports the findings from a BD clinical trial — the three causes of vaginitis (bacterial vaginosis [BV], vulvovaginal candidiasis [VVC] or Trichomonas vaginalis [TV]) were studied to compare clinician assessment with results from a molecular test.
- The study compared clinician diagnosis of vaginitis to results of a vaginal panel assay performed on the BD MAX™ System, an FDA-market authorized molecular test that uses nucleic acid amplification to detect the microbial causes of BV, VVC, and TV.
- “We really do women a medical disservice when we do not use the best tools we have available to diagnose the cause or causes of the symptoms that drove them to seek health care,”.
