I-Immune Thrombocytopenia Isivivinyo Sokuqala Somtholampilo Ngokusebenzisa Ukwelashwa Okusha

A BAMBA MahhalaRelease 3 | eTurboNews | eTN
Isithombe sikaLinda Hohnholz
Ibhalwe ngu Linda Hohnholz

I-InnoCare Pharma, inkampani ehamba phambili ye-biopharmaceutical, imemezele namuhla ukuthi isiguli sokuqala sinikezwe isivivinyo somtholampilo seSigaba II se-Bruton's tyrosine kinase (BTK) inhibitor orelabrutinib yokwelapha i-immune immune thrombocytopenia (ITP) eChina.

I-Primary immune thrombocytopenia (ITP), ebizwa nangokuthi i-idiopathic thrombocytopenic purpura, isifo esitholwa yi-immune mediated esibonakala ngokuncipha kwezibalo zamaplatelet egazi, okuholela engcupheni eyengeziwe yokulimaza nokopha[i]. I-pathogenesis eyinhloko ye-ITP ukulahlekelwa ukubekezelelana komzimba kuma-platelet auto-antigens. Lokhu kungabekezelelani kwamasosha omzimba kuholela ekwandeni kokubhujiswa kweplatelet kanye nokuncipha kokukhiqizwa kweplatelet kuma-megakaryocyte ngama-autoantibodies kanye ne-cytotoxic T lymphocyte.

Iziguli ezingaba ngu-70% kuphela ezisabela ekwelashweni komugqa wokuqala, ezinye iziguli zisaphika noma zisabuyela emuva ngemva kokwelashwa okuhlangene, ngakho-ke kuyadingeka ukuhlola okuhlosiwe kokwelapha okusha. Ukuvinjelwa kwe-BTK kungase kunciphise ukubhujiswa kweplatelet ngokuvimbela ukusebenza kwe-B cell kanye nokukhiqizwa kwama-autoantibody.

Izehlakalo zonyaka ze-ITP kubantu abadala zicishe zibe yizigameko ezintsha ezingu-2–10 kubantu abangu-100,000[ii],[iii]. Abantu abadala abangaphezu kweminyaka engama-60 basengozini enkulu ye-ITP, futhi abesifazane bokubeletha basengozini enkulu kunabesilisa beqembu leminyaka efanayo.

UDkt. Jasmine Cui, umsunguli, uSihlalo kanye no-CEO we-InnoCare uthe, “Ayikho i-BTK inhibitor evunyelwe ukwelapha iziguli ezine-ITP emhlabeni. I-BTK iyi-kinase eyinhloko endleleni yokubonisa i-B cell receptor, ebalulekile ekusebenzeni kwama-lymphocyte e-B, ama-macrophage namanye amaseli omzimba kanye nokukhiqizwa kwamasosha omzimba ohlelweni lwe-pathological ye-ITP. I-Orelabrutinib inokukhetha okuphezulu okuhlosiwe okunephrofayili yokuphepha, okulindeleke ukuthi ilethe izindlela zokwelapha ezintsha ezigulini ze-ITP. "

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Isithombe sikaLinda Hohnholz

Linda Hohnholz

Umhleli omkhulu we eTurboNews ezinze eTN HQ.

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