Ukuxilongwa kwe-Milestone kanye nokwelashwa kwamaseli omdlavuza wobuchopho bezingane

A BAMBA MahhalaRelease 3 | eTurboNews | eTN
Isithombe sikaLinda Hohnholz
Ibhalwe ngu Linda Hohnholz

I-Genegoggle yembula izici ezibonakalayo ze-chromatin (ukugoqa kwe-3D DNA) yamaseli asuselwa ku-diffuse intrinsic pontine gliomas (DIPG). Umsebenzi wamanje uqondiswe ekutholeni abathintwayo be-DNA-DNA abangasetshenziswa njengezimaka zohlobo lweseli ukuze kubonakale amaseli e-DIPG nanjengezinjongo zokulethwa kwezidakamizwa. U-Michał Marzęcki, Isikhulu Esiyinhloko Sezobuchwepheshe, umemezele ukuthi “lesi esinye igxathu elibalulekile eliqinisekisa ukufaneleka kwesixazululo sethu nokwandisa isiphakamiso sethu senani”.     

Olunye lwezimpawu ze-DIPG ukuguqulwa kwe-histone H3.3 okuholela ekushintsheni kwe-amino acid lysine ibe yi-methionine (K27M), okuthonya izinqubo ze-epigenetic. I-Genegoggle ikhombe ngempumelelo inqwaba yoxhumana nabo be-DNA-DNA (okubizwa nangokuthi i-DNA loops) ngokukhethekileyo kumaseli e-DIPG aphethe ukuguqulwa kwe-K27M kanye nezinguquko kuphrofayela ye-H3K27me3 uma kuqhathaniswa namaseli avamile. Ngokusebenzisa ubuchwepheshe be-epigenetic obusezingeni eliphezulu, eziningi zalezi zihibe ze-DNA ziye zaxhunyaniswa nenkulumo ehlukile yofuzo kanye nokufinyeleleka okuhlukile kwe-chromatin.

"Le miphumela isazisa mayelana namaphrofayili ambalwa okuguqulwa kwe-histone ukuchaza kangcono izifunda ze-chromatin zamaseli e-DIPG, okuzosivumela ukuthi sihlonze izici ezintsha nezihlosiwe zomtholampilo," kusho u-Jakub Mieczkowski, PhD, kanye neSikhulu Esiphezulu. Imininingwane itholwe ngesikhathi sobambiswano lwe-Illumina Accelerator futhi ngokubambisana noProf. Jacek Majewski waseMcGill University. Lapho ebuzwa ngekusasa le-Genegoggle, Isikhulu Esiyinhloko Sezamabhizinisi u-Marcin Kruczyk, PhD, sathi, “sikholelwa ukuthi simi kahle emzuliswaneni olandelayo wokuqoqwa kwezimali ukuze siqhubekisele phambili lolu hambo”.

Mayelana ne-diffuse intrinsic pontine glioma (DIPG)

I-Diffuse intrinsic pontine glioma wuhlobo oluvame kakhulu lomdlavuza wesiqu sobuchopho ezinganeni. Ukuphila okumaphakathi kwezingane ezine-DIPG kungaphansi konyaka owodwa kusukela ekuxilongweni, futhi ukuthuthukiswa okuncane ekusindeni okuzuziwe emashumini eminyaka. Indlela yamanje yokuxilonga ukuhlolwa kwe-MRI (i-magnetic resonance imaging) futhi ngokuvamile kwenzeka lapho izimpawu sezithuthukile. Uphawu lofuzo lwe-DIPG ukuguqulwa kofuzo H3F3A olufaka i-histone H3.3.

Mayelana umbhali

Isithombe sikaLinda Hohnholz

Linda Hohnholz

Umhleli omkhulu we eTurboNews ezinze eTN HQ.

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