Ucwaningo Olusha Lomphumela Wokunqanda Uhudo Lwe-Cashew Stem Bark Extract

I-Anacardium occidentale (Ao), isihlahla se-cashew esivamile, isitshalo osekunesikhathi eside saziwa ezinhlelweni zemithi yendabuko ngenxa yamandla aso okwelapha. Ngokwesibonelo, izingxenye ezihlukahlukene zalesi sihlahla sasezindaweni ezishisayo, amaqabunga, amagxolo, uhlamvu lwembewu, noshingamu, zaziwa ngokuthi zinamandla okulwa nesifo sohudo. Nokho, izindlela eziqondile zokusebenza zihlala ziyimfihlakalo.            

UDkt. Kayode E. Adewole ovela eNyuvesi Yesayensi Yezokwelapha, eNigeria, kanye nozakwabo bazame ukufiphaza lezi zindlela ngokuphenya umsebenzi wokulwa nesifo sohudo wegxolo lesiqu lesihlahla se-cashew. Ukuphawula kwabo okuthembisayo kusanda kushicilelwa ku-Journal of Pharmaceutical Analysis.

Kubangelwa izici ezihlukahlukene njengokungabekezelelani kokudla, izifo ezibangelwa amagciwane, izidakamizwa, nokuphazamiseka kwamathumbu, isifo sohudo siyinkinga enkulu yezempilo yomphakathi, futhi sibangela ukufa kwezingane okukhulu. Ngokuvamile, lesi sifo sibonakala njengokwanda kwe-gut motility. Ukuhlola indlela yokulwa nesifo sohudo yokukhishwa kwegxolo le-cashew stem, abacwaningi bagxile emigudwini yeselula kanye nabadlali ababalulekile bemolekyuli ababambe iqhaza ekunyakazeni kwamathumbu okungavamile futhi baklama uchungechunge lokuhlola okusekelwe elebhu.

UDkt. Adewole uyachaza, “Isifo sohudo siphumela ekukhuleni kwemisipha ebushelelezi emathunjini, ngokuvamile alawulwa izindlela ezintathu ze-neurophysiological, i-dopaminergic, i-cholinergic, ne-serotonergic. Ngakho-ke, indlela yethu yokuhlola yayiwukuvuselela ngokuzenzakalelayo ukuhamba kwesisu ngokusebenzisa ngayinye yale mizila bese sibona ukuthi iyiphi yalezi evinjwe igxolo lesiqu se-cashew. Ukuhlola kwethu kwahlukaniswa kwaba izingxenye ezimbili, ku-vivo, kwenziwa kumagundane aphilayo, kanye ne-in vitro, eyenziwa kumaseli amathumbu.”

Ithimba linikeze izidakamizwa ezikhuthaza ukuhamba kwamathumbu, okuyi-metoclopramide (i-dopamine receptor antagonist), i-carbachol (i-acetylcholine receptor agonist), ne-serotonin (eshukumisa ama-serotonergic receptors), ukuhlukanisa amaqembu amagundane. Amanye amaqembu amathathu athola imishanguzo efanayo kodwa afafazwa nge-cashew stem bark extract.

Bathole ukuthi ingxenye elungisiwe ye-ethyl acetate ye-extract (ebhalwe ukuthi AoEF) ivimbele kakhulu indlela ye-cholinergic yokukhipha isisu kanye nokuhamba kwesisu kodwa ayizange ibe nomthelela kwezinye izindlela ezimbili, inikeze ukuqonda okungcono kwendlela yokusebenza ye-extract.

Njengengxenye yokuhlolwa kwe-in vitro, abacwaningi bahlukanise imichilo emathunjini e-Guinea pigs futhi bathola ukuthi ekugxiliseni okuphezulu, i-AoEF ixegise kahle le micu ngokubuyisela emuva. Lokhu kubonwe ngisho nasemigqeni ebelashwe ngaphambilini nge-AoEF yase iphathwa ngama-molecule e-prokinetic afana ne-histamine, i-serotonin, ne-acetylcholine.

Ngokuqhubekayo, lisebenzisa i-gas chromatography-mass spectroscopy, ithimba lihlonze izingxenye ezingama-24 ezikhona ku-AoEF. Ucwaningo olusekelwe ku-Bioinformatics lwembula ukuthi phakathi kwalezi zinhlanganisela, i-octadecanoic acid 2-(2-hydroxylethoxy) ester ethyl yayinesibopho esiphezulu sokubopha i-muscarinic acetylcholine receptor M3 (CHRM3). Lokhu kwavumela ithimba ukuthi lihlanganise ubufakazi obuvela kuzo zonke izivivinyo ezihlukene futhi lifinyelele kumodi yesenzo esingase sibe khona sokukhishwa.

Ukuhlanganisa amandla olwazi lwendabuko kanye nesayensi yesimanje, uDkt Adewole kanye nethimba lakhe banethemba lokuthi ukutholakala kwabo kuzokhuthaza ukwakhiwa kwamakhambi amasha angabizi kakhulu okwelapha nokulawula isifo sohudo.