I-John Theurer Cancer Centre e-Hackensack University Medical Centre imemezele namuhla ukuthi sebelaphe isiguli sokuqala ezweni nge-DSP-0390, umuthi omusha ophenywayo we-glioblastoma (GBM) ephinde yabuyela emuva kanye namanye ama-anaplastic gliomas.
I-Glioblastoma (GBM) ingenye yezinhlobo ezinonya kakhulu zomdlavuza wobuchopho ovame ukuvela naphezu kokwelashwa okujwayelekile okufana nokwelashwa ngamakhemikhali nemisebe. Ukusinda ngaphezu kweminyaka emihlanu akuvamile, futhi ukwelashwa okusha kudingekile kakhulu.
I-DSP-0390, i-ejenti entsha yophenyo eyakhiwe yi-Cambridge, e-Massachusetts-based Sumitomo Dainippon Pharma Oncology, iyisivimbeli se-emopamil-binding protein (EBP), i-molecule ku-cholesterol biosynthesis. I-DSP-0390 ayizange ivunyelwe yi-US Food and Drug Administration futhi ukuphepha nokusebenza kwayo akukasungulwa.
"Imizimba yethu idinga i-cholesterol ukuze yakhe amangqamuzana anempilo futhi lawo maseli abonisane," kusho uSamuel A. Goldlust, MD, uMqondisi Wezokwelapha we-Neuro-Oncology. "Kodwa amangqamuzana e-GBM angaphoqa ukukhiqizwa kwe-cholesterol ibe yi-overdrive, okuholela ekukhuleni kwesimila futhi ukuvimbela i-EPB kungase kuvimbele lokhu kukhula."
Lolu cwaningo lwe-multicenter, lweSigaba 1/2 somhlaba wonke luhlelelwe ukubhalisa iziguli ezingama-70 ezikhungweni ezinhlanu zesimila sobuchopho e-US naseJapan.
"Izilingo zomtholampilo ku-GBM zisifundise ukuthi ukwelashwa kwendabuko akwanele ukunqoba lesi simila esiyinselele," kusho uGeorge J. Kaptain MD, uMqondisi we-Neurosurgical Oncology. "Kuyilungelo ukukwazi ukunikeza iziguli zethu ukufinyelela okulula kumanoveli, izindlela zokwelapha ezihloswe ngamangqamuzana ophenyo njenge-DSP -0390, emzamweni wethu oqhubekayo wokwelapha ukusiza ukukhulisa ukusinda nokunciphisa imiphumela emibi."