Isidakamizwa esisha sokuhlola sokwelapha i-tics evela ku-Tourette Syndrome

A BAMBA MahhalaRelease 8 | eTurboNews | eTN
Isithombe sikaLinda Hohnholz
Ibhalwe ngu Linda Hohnholz

Ngokocwaningo olusha lokuqala, izingane kanye nentsha ene-Tourette syndrome ebelashwa ngesidakamizwa esihlolwayo esibizwa ngokuthi i-ecopipam ingase ibe ngcono imiphumela ekuhlolweni kokuqina kwe-tic ezinyangeni ezintathu kamuva. Ucwaningo olukhishwe namuhla, Mashi 30, 2022, luzokwethulwa eMhlanganweni Wonyaka wama-74 we-American Academy of Neurology ozoba mathupha eSeattle, Ephreli 2 kuya ku-7, 2022 futhi cishe, Ephreli 24 kuya ku-26, 2022. isifo sezinzwa esibonakala ngama-motor and tic tics, okuwukunyakaza okuphindaphindayo nokuphimisa okubangelwa isifiso esingenakuvinjelwa sokuwakhiqiza.

"Imiphumela yethu iyajabulisa, ngoba iphakamisa ukuthi i-ecopipam ikhombisa isithembiso njengokwelashwa kokunciphisa inani, imvamisa kanye nokuqina kwe-tics abantu abasha abahlangabezana ne-Tourette syndrome," kusho umlobi wocwaningo uDonald L. Gilbert, MD, we-Cincinnati Children's Hospital Medical. Isikhungo e-Ohio, kanye noFellow of the American Academy of Neurology. “Lokho kuyiqiniso ikakhulukazi ngoba abantu abaningi abanalesi sifo abadla imishanguzo etholakalayo njengamanje basenezimpawu ezibaqeda amandla noma bakhuluphale noma eminye imiphumela emibi.”

Ucwaningo lubheke izingane ezingu-149 nentsha ephakathi kweminyaka eyisithupha nengu-17 ene-Tourette syndrome. Bahlukaniswa ngamaqembu amabili: abangama-74 belashwa nge-ecopipam, abangama-75 nge-placebo.

Abacwaningi balinganise ubukhali be-tics yabahlanganyeli besebenzisa izikali ezimbili ezivamile zokulinganisa i-tic ekuqaleni kocwaningo baphinda futhi ngemva kwezinyanga ezintathu. Ukuhlolwa kokuqala kukala i-motor and vocal tics futhi kunamaphuzu aphezulu angama-50. Ukuhlolwa kwesibili kubheka izimpawu ze-tic zizonke kanye nobukhulu bokukhubazeka okuhlobene ne-tic. Inenani eliphakeme elingu-100. Izikolo eziphakeme kunoma yikuphi ukuhlolwa zikhombisa izimpawu ezinzima kakhulu nomthelela ongemuhle empilweni yansuku zonke.

Ngemuva kwezinyanga ezintathu, abacwaningi bathola ukuthi iqembu elithatha i-ecopipam lalinama-tics ambalwa futhi aqinile futhi lenza kangcono ngokujwayelekile ngokwawo womabili amaphuzu wokuhlola.

Ngokwesilinganiso, ababambiqhaza abathatha i-ecopipam bathuthukise amaphuzu abo e-motor tic tic ukusuka ku-35 kuya ku-24, ukwehla ngo-30%. Lokho kuqhathaniswa nalabo abathatha ama-placebos, abathuthuke besuka esilinganisweni sobunzima be-tic amaphuzu obungama-35 ukuya ku-28 ngesikhathi esifanayo, ukwehla ngo-19%.

Lapho abacwaningi bebheka amaphuzu ohlolo lwesibili ukuze bahlole ukusebenza kahle okuphelele kwe-ecopipam, bathole ukuthi labo abaphuza imithi bathuthuke besuka esilinganisweni samaphuzu angama-68 kuya ku-46, ukwehla ngo-32%, uma kuqhathaniswa nalabo abathatha i-placebo, abathuthuke ukusuka ku-66 kuya ku-54. isilinganiso samaphuzu angama-20 kuye kwangama-XNUMX, ukwehla ngo-XNUMX%.

U-Gilbert waphawula ukuthi u-34% wabahlanganyeli abathatha i-ecopipam baba nemiphumela engemihle efana nobuhlungu bekhanda nokukhathala, kuyilapho u-21% walabo abathatha i-placebo benzile.

"Ucwaningo lwangaphambili lubonisa izinkinga nge-dopamine, i-neurotransmitter ebuchosheni, ingase ihlotshaniswe nezimpawu ze-Tourette syndrome, nokuthi i-D1 dopamine receptors idlala indima ebalulekile," kusho uGilbert. “Ama-Dopamine receptors atholakala ohlelweni lwezinzwa olumaphakathi. Lapho bethola i-dopamine, bakha amasignali emisebenzi ehlukahlukene yengqondo nengokomzimba njengokunyakaza. Ama-receptors ahlukene asiza ukulawula imisebenzi ehlukene. Nakuba i-ecopipam isesigabeni sokuhlola, iwumuthi wokuqala ukukhomba isamukeli se-D1 esikhundleni sesamukeli se-D2, okuyisona esiqondiswe emithini emakethe njengamanje. Imiphumela yethu ikhombisa ukuthi i-ecopipam ifanelwe wucwaningo olwengeziwe njengendlela yokwelapha esebenzayo ye-Tourette syndrome kubantu abasha esikhathini esizayo.”

Umkhawulo wocwaningo ubude balo bezinyanga ezintathu. UGilbert waphawula ukuthi nakuba kuyindinganiso yalolu hlobo locwaningo, kuzobaluleka ukufunda uma ukuthuthukiswa kwezimpawu kuqhubeka isikhathi eside.

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Isithombe sikaLinda Hohnholz

Linda Hohnholz

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