Ucwaningo Olusha Lweziguli Zomdlavuza Wesikhumba

A BAMBA MahhalaRelease 1 | eTurboNews | eTN
Isithombe sikaLinda Hohnholz
Ibhalwe ngu Linda Hohnholz

I-Caris Life Sciences® yethula okutholakele okunikeza ukuqonda okujulile kokuthi ukubonakaliswa kwesimila kwezakhi zofuzo ezihlobene nezinga lokuchayeka kwezidakamizwa, okuhlungwe ngesimo se-p53, kuhlotshaniswa nemiphumela yomtholampilo ezinhlotsheni ezijwayelekile ze-chemotherapeutic ezisetshenziselwa ukwelapha umdlavuza we-metastatic colorectal (CRC). Le miphumela izokwethulwa eMhlanganweni Wonyaka we-2022 American Association for Cancer Research (AACR) ozoba ngo-Ephreli 8 - 13, 2022 eNew Orleans, eLouisiana.

Ucwaningo olunoqwembe olunesihloko esithi, "Amasiginesha ofuzo olwelwe yizidakamizwa ezibikezelayo kanye nezibikezelo zeziguli ezinomdlavuza we-colorectal ezenziwe zaba ngezakho ngokusekelwe esimweni se-p53 kanye nokwelashwa nge-FOLFOX, 5-FU, oxaliplatin noma irinotecan" (Abstract #1231), yayiholwa nguWafik El-Deiry , MD, Ph.D., FACP, Umqondisi we-Legorreta Cancer Centre yase-Brown University, uDean Ohlangene e-Warren Alpert Medical School, ilungu le-Caris' Precision Oncology Alliance (POA). I-Caris' POA iyinethiwekhi ekhulayo yezikhungo zomdlavuza ezihamba phambili emhlabeni wonke ezisebenzisana ukuze kuthuthukiswe ukunemba kwe-oncology kanye nocwaningo oluqhutshwa yi-biomarker. Lo msebenzi wethulwa eNew Orleans nguLindsey Carlsen, umfundi oneziqu zePathobiology e-EL-DEIRY Lab eBrown.

Umgomo walolu cwaningo bekuwukukhomba ama-biomarker aqagelayo ama-chemotherapies asetshenziswa ku-CRC. Ucwaningo lusebenzise imigqa yeseli ye-CRC ukuze luhlonze izakhi zofuzo ezivezwe ngokuhlukile ezilandela ukwelashwa kwe-5-fluorouracil, irinotecan, noma i-oxaliplatin futhi zahlukanisa amasiginesha ngokusekelwe esimweni se-p53. Kulezi zifundo ze-in vitro, abacwaningi babe sebehlola ukuthi lezi zakhi zofuzo namasignesha ofuzo zingabikezela yini imiphumela yesiguli se-CRC elandela ukwelashwa ngamakhemikhali (FOLFOX, 5-fluorouracil, irinotecan noma oxaliplatin). Amasampula esiguli angu-2,983 kanye ne-6,229 yokulahlekelwa-ukusebenza kwe-p53 CRC ahlaziywa ukulandelana kwesizukulwane esilandelayo se-DNA/RNA ku-Caris Life Sciences. Imiphumela yokusinda yomhlaba wangempela ithathwe kudatha yezimangalo zomshwalense kanye nezilinganiso ze-Kaplan-Meier. Kokubili ukubonakaliswa kofuzo okubikezelayo nokungabikezeli kube nomthelela omkhulu emiphumeleni yokusinda elandela ukwelashwa kwezidakamizwa ezithile.

"Lolu cwaningo lusisiza ukuthi siqonde ukubaluleka kokuthi amasiginesha ofuzo anakho ekuboniseni ikhono lokuqagela elithuthukisiwe uma kuqhathaniswa nemibhalo ngayinye," kusho u-El-Deiry. "Ukuhlanganisa ucwaningo oluyisisekelo nolwezempilo, lolu cwaningo lusivumela ukuthi siqonde kangcono ukuthi yiziphi izindlela zokwelapha ezingazuzisa iziguli ze-CRC." Ucwaningo luthole ukuthi ukubonakaliswa kwesimila kwezakhi zofuzo ezihlobene nokuchayeka kwezidakamizwa kungabikezela imiphumela ngemuva kokwelashwa ngamakhemikhali:

• I-EGR1 ephezulu kanye ne-FOS mRNA ibikezela ngokuzimela impendulo ku-FOLFOX ezigulini ezinamathumba ohlobo lwasendle lwe-p53.

• I-CCNB1 mRNA ephansi ihlotshaniswa nokubikezelwa okuhle kweziguli ze-CRC ezinamathumba aphethe ukulahlekelwa kwe-TP53 kokushintsha kokusebenza.

• Ukubonakaliswa okuphansi kwe-BTG2 kubikezela ukubikezelwa okungcono kweziguli ezine-MSI-High TP53 eguqukile.

• Amasiginesha ofuzo angabonisa ikhono elithuthukisiwe lokuqagela uma kuqhathaniswa nemiphumela yombhalo ngamunye.

"I-Caris igxile kuma-biomarkers angakwazi ukubikezela impendulo yesiguli emithi yokwelapha entsha, kodwa futhi i-chemotherapies ezame futhi eyiqiniso efana ne-FOLFOX," kusho u-W. Michael Korn, MD, Isikhulu Esiyinhloko Sezokwelapha e-Caris. "Sijabule ukubona ikhono lokucwaninga lokuhumusha linikwa amandla idatha ye-multi-omic namathuluzi okuhlaziya athuthukiswe u-Caris futhi asaqhubeka nokuthuthuka kuwo."

Iphrofayili ye-molecule ye-Caris ebanzi ihlola i-exome yonke (i-DNA), i-transcriptome yonke (i-RNA) kanye nokuchazwa kwephrotheni, ihlinzeka ngensiza engenakuqhathaniswa kanye nendlela efanelekile yokuqhubekela phambili yokwenza ucwaningo lokuhumusha ukuze kusheshiswe ukutholwa, ukuxilongwa, ukuqapha, ukukhethwa kokwelashwa nokuthuthukiswa kwezidakamizwa. ukuthuthukisa isimo somuntu.

U-Caris uzokwethula idatha eyengeziwe evela ezifundweni ezibonisa indima ebalulekile yomuthi onembayo kanye nokwenza iphrofayela yamangqamuzana ekwelapheni umdlavuza. Zonke izethulo zizotholakala ku-inthanethi ngewebhusayithi kaCaris kusukela ngo-April 8, 2022.

Izethulo Ezengeziwe Zembula Umthelela Wokuprofetha Okuphelele Kwemolekyuli kanye Nokusebenza Okungenzeka Komtholampilo

• Ukubonakaliswa okuphelele kwezinguquko ze-FGF/FGFR kumdlavuza wamabele ohlaselayo (Abstract #5793) Ukusayinwa kwe-FGFR kuyisisekelo sokusabalala kwamangqamuzana omdlavuza, ukufuduka, i-angiogenesis kanye nokuphila; Ukuguqulwa kwe-FGFR sekusebenzeke ngokomtholampilo enanini elandayo lezinhlobo zomdlavuza. Lolu cwaningo luhlole izehlakalo kanye nokuchazwa kwezinguquko eziningi ze-FGF/FGFR kumdlavuza webele ohlaselayo ongaphezu kuka-12,000 futhi lwagqamisa ukungafani okukhulu kwezinguquko ze-FGF/FGFR ezinhlotsheni ezihlukahlukene ze-histologic kanye ne-molecular subtypes kanye nezindawo ezahlukene ze-metastatic zomdlavuza webele. Ngaphezu kwalokho, izinhlangano zokuguqulwa kwe-FGFR kanye nokumelana nokwelashwa kuboniswe kusizindalwazi esikhulu somtholampilo esinemiphumela ehambisanayo yamangqamuzana.

• Izici ze-Genomic nezivikeli mzimba ze-EGFR subtypes kumdlavuza wamaphaphu ongewona omncane (NSCLC) (Abstract #4119)Ngenkathi amathumba e-EGFR aguquguqukayo e-NSCLC ngokuvamile amelana ne-PD-1/PD-L1 inhibitors, isethi encane yeziguli ingaba nezimpendulo ezihlala isikhathi eside. . Izicubu eziguquguqukayo ze-EGFR zibonisa i-heterogeneity ephawulekayo yamangqamuzana, nokho, kukhona ukuntula ukucaca kumaphrofayili we-genomic kanye ne-immune ye-EGFR mutation subtypes, futhi ukucaciswa okwengeziwe kwalokhu kungasiza ekuboneni iziguli ezingase zisabele ekwelashweni okusekelwe kumasosha omzimba. Ngokusebenzisa idatha yamangqamuzana e-multi-omic ekhiqizwe i-Next-Generation Sequencing of DNA ne-RNA eqenjini elikhulu lamathumba e-NSCLC, lolu cwaningo luqinisekisa ukuncipha kokuzivikela komzimba okuhlotshaniswa nezinhlobo eziningi zezinguquko ze-EGFR ezibonakaliswa ama-biomarker afaka i-PD-L1, TMB ne-CD8+ T. ukungena kweseli; futhi yembula ukuguqulwa kwe-EGFR okungajwayelekile okuhlotshaniswa nephrofayili yokuzivikela yomzimba evumayo engaphakamisa ukusabela ekwelashweni kwamasosha omzimba.

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Isithombe sikaLinda Hohnholz

Linda Hohnholz

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