Abaphenyi baseNagourney Cancer Institute kanye neMetabolomycs, Inc. bazobika namuhla eMhlanganweni Wonyaka we-American Association for Cancer Research (AACR) eNew Orleans ukuthi babikezele ukusinda kweziguli ezinomdlavuza we-ovarian ngokulinganisa amasignesha e-metabolic ku-tumor microenvironment. Imiphumela ingase iqinise ikusasa lapho izazi ze-oncologists zinganquma kusenesikhathi ukuthi isiguli sizosabela kanjani ekwelashweni ukuze kuthuthukiswe imiphumela yokusinda.
Ngokwabacwaningi, ibhayoloji yesimila somuntu ikhombisa ukuqhubeka kusuka kokujwayelekile kuya ekuguqukeni okubi kuya ekumelaneni nezidakamizwa konke okuqhutshwa ukuhlelwa kabusha kwe-metabolic emhlabeni jikelele.
"Siye sabonisa ngaphambilini ukuthi ukumelana ne-platinum ezinkingeni ze-gynecologic kubikezelwa izinguquko ze-metabolic ezilinganiswa ku-plasma yeziguli ngesikhathi sokuxilongwa," kusho uDkt Robert Nagourney, uMsunguli kanye noMqondisi Wezokwelapha we-Nagourney Cancer Institute. "Manje sikhombisa ukuthi i-tumor microenvironment elinganiswa emithonjeni yezindaba ye-human tumor 1o culture explant ihlinzeka ngemininingwane efanayo ekuphenduleni kwezidakamizwa ekwelapheni okusekelwe kwiplatinamu."
Umdlavuza wesibeletho yimbangela ehamba phambili yokufa komdlavuza wabesifazane. Nakuba u-80% wezifo zesibeletho zisabela ekwelapheni okusekelwe ku-platinum, izimo eziningi ziyaphinda, futhi iziguli ziyafa phakathi neminyaka emihlanu. Ngentshisekelo ekhulayo kumetabolism yomuntu njengengxenye ebalulekile yebhayoloji yomdlavuza, lo mbiko ngomdlavuza wesibeletho ungowakamuva kakhulu ukuhlaziya okuningana kweqembu emidlavuza eminingi ethuthukile eqinisekisa indima ye-metabolomics ekunqumeni ukusinda.
Abaphenyi benze i-quantitative tandem Mass Spectrometry (MS/MS) kumidiya yesiko lezicubu zokufakelwa komdlavuza wesibeletho somuntu ukuze kuhlolwe amasiginesha we-metabolic we-tumor microenvironment kulandela izinsuku ezi-3 zesiko ku-RPMI 1640 eguquliwe.
I-Mass Spectrometry eyenziwe kwabezindaba ze-tissue yeziguli eziyi-11 iqhathanise iziguli eziyi-8 ezithole ukuxolelwa okuphelele kwe-pathologic (pCR) neziguli ezintathu ezinesifo esisalayo zonke zilandela ukwelashwa ngamakhemikhali okungeniswa nge-Carboplatin kanye ne-Paclitaxel. Ukuhlaziya kwakuhlanganisa ama-amino acid, ama-amine e-biogenic, ama-hexose, ama-phosphatidylcholines, i-lyso-phosphatidylcholines nama-sphingomyelins.
“Ngokuqonda okunjalo, sisonqenqemeni lokunquma ngokunembe kakhudlwana inkambo yokwelapha engcono kakhulu yalabo abanamathumba esibelethweni,” kusho uDkt. Nagourney.