Ukuhlolwa Okusha Komtholampilo Kwe-Relapsed Acute Lymphoblastic Leukemia

A BAMBA MahhalaRelease 3 | eTurboNews | eTN
Isithombe sikaLinda Hohnholz
Ibhalwe ngu Linda Hohnholz

I-JW Therapeutics imemezele imvume ye-Investigational New Drug (IND) evela ku-National Medical Products Administration (NMPA) yaseChina ukuze kucwaningwe umjovo we-anti-CD19 autologous chimeric antigen receptor T (CAR-T) cell immunotherapy umkhiqizo iCarteyva® (relmacabtagene autoleucel injection) ekwelapheni izingane kanye neziguli ezikhulile ezine-B-cell acute lymphoblastic leukemia (r/r B-ALL) ebuyele emuva noma ephikisayo.

I-B-cell acute lymphoblastic leukemia (B-ALL) iyisifo esiyingozi esivame kakhulu kwezingane[1]. Ukumelana nama-ejenti e-chemotherapeutic okuholela ekubuyeni kwesifo kanye nokuqhubekela phambili, kanye nokusinda kulandela ukuphindeka kubi ezigulini ezine-B-ALL. I-Salvage chemotherapy ingaba inketho, kodwa akwanele ukwelapha isifo esihlasele kabusha noma esihlaselayo. Ukusinda kwesikhathi eside kwakunomkhawulo ngenxa yokusabela okungekuhle, izinga eliphansi lokuxolelwa, kanye nezinga eliphezulu lokuphinda ugule ngemva kokwelashwa ngamakhemikhali okusindisa. Okwamanje, akukho ukwelashwa okujwayelekile okusebenzayo kwe-r/r B-ALL. I-allogeneic hematopoietic stem cell transplantation (i-allo-HSCT) ivele njengesu elithembisayo, nokho, izinga lokusinda lesikhathi eside alikakwazi ukuzuza ukwaneliseka[2]. Ukubuya kwezifo ngemva kokwelashwa kuseyinselele enkulu, futhi izinketho zokwelapha zenoveli zisadingeka ngokushesha ukuze kunwetshwe ukuphila kwesikhathi eside kweziguli ezine-r/r B-ALL.

Lolu cwaningo (JWCAR029-006) isigaba I, ilebula evulekile, ingalo eyodwa, ucwaningo lokukhuphuka komthamo e-China, oluhlose ukuhlola ukuphepha, ukusebenza kahle, kanye nephrofayili ye-pharmacokinetics ye-Carteyva® ezigulini zezingane kanye nentsha yabantu abadala abane-r/r. B-ALL, kanye nokunquma umthamo onconyiwe wesigaba II (RP2D).

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Isithombe sikaLinda Hohnholz

Linda Hohnholz

Umhleli omkhulu we eTurboNews ezinze eTN HQ.

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