Inketho Entsha Yokuhlola Iziguli Ezisengozini Enkulu Yomdlavuza We-Pancreatic

A BAMBA MahhalaRelease 5 | eTurboNews | eTN
Isithombe sikaLinda Hohnholz
Ibhalwe ngu Linda Hohnholz

I-Hackensack University Medical Center yethule uhlelo olusha lokuqapha oluhlola abantu abasengozini enkulu yokuthola umdlavuza wamaphaphu.             

Ukuhlolwa kwe-IMMray® PanCan-d ukuhlolwa kwegazi lokuqala emakethe okunikezelwe ekutholweni kusenesikhathi kwe-familia noma i-pancreatic ductal adenocarcinoma (PDAC).

Iziguli ezifanele zizothola kokubili ukuhlolwa kwe-imaging kanye nokuhlola inoveli ye-biomarker ekala impendulo yamasosha omzimba esifweni se-pancreatic egazini.

"Umdlavuza utholwa ngaphambilini, nethuba elingcono lokwelashwa ngempumelelo," kusho uRosario Ligresti, MD, isikhulu seGastroenterology eHackensack University Medical Center, iNational Pancreas Foundation Center of Excellence kusukela ngo-2013, lapho lolu hlelo olusha luhlinzekwa njengengxenye uhlelo lwesibhedlela lokuqapha ingozi enkulu yomdlavuza we-pancreatic.

Ngeshwa, ucwaningo lubonisa cishe ingxenye yesine kuphela yabantu abafanelekela ukubhekwa engcupheni enkulu empeleni basebenzisa leli thuba, kodwa uDkt. Ligresti ukholelwa ukuthi lokhu kuhlolwa kwegazi okusha kuzoshintsha umdlalo.

"Umdlavuza we-pancreatic, omunye wezinhlobo ezibulala kakhulu zomdlavuza, kunzima ukusheshe uthole, esigabeni lapho ukuhlinzwa kokuhlinzwa, okuwukuphela kwendlela yokwelapha, kungenzeka," kuchaza uDkt. Ligresti. “Lokhu kuhlolwa okusha kukhonjiswe ukuthi kuthola umdlavuza we-pancreatic kusenesikhathi ezigulini ezisengozini enkulu, ngenhloso yokuwuthola ngaphambi kokuba zithole ithuba lokusabalala kwezinye izicubu.”

Ubani obhekwa njengabasengozini enkulu? 

Umdlavuza we-pancreas ungase ugijime emndenini futhi/noma ungaxhunyaniswa nezimo zofuzo ezandisa ubungozi bezinye izinhlobo zomdlavuza. Lokhu kubizwa ngokuthi umdlavuza wama-pancreas womndeni futhi kuhlanganisa izimo ezinganeni zakini, abazali nogogo nomkhulu ngezizukulwane zamanje zomndeni wakho. Wena nomndeni wakho ningase nibe sengcupheni eyengeziwe uma izihlobo ezi-2 noma ngaphezulu ze-degree yokuqala noma okungenani amalungu ama-3 omndeni etholwe enomdlavuza we-pancreatic.

Lithini izinga lamanje lokunakekela ekuhlolweni?

Njengamanje, ukuhlolelwa amanyikwe ngomdlavuza kwenziwa kusetshenziswa i-MRI noma i-endoscopic ultrasound (EUS). Lokhu ukuhlolwa okukhethekile okubandakanya i-endoscope kanye ne-high-frequency ultrasound yokuthwebula ama-pancreas ngokunembile. Ukuhlolwa kwenziwa minyaka yonke futhi kokubili kunobuhle nokubi. I-MRI ingaba nzima, ibize futhi idle isikhathi. I-EUS ihilela i-endoscopy engavamisile kancane futhi idinga ukuzila ukudla nokuthulisa. IHackensack University Medical Center ibilokhu yenza ukuhlolwa kwama-pancreas ngale mfashini iminyaka eminingi. Ngaphambili, akukho ukuhlolwa kwegazi okukhethekile noma okunembile okuye kwatholakala ukuze kuvunyelwe ukuhlolelwa umdlavuza wamanyikwe.

Ubani ofanelekela lokhu kubhekwa okusha komdlavuza we-pancreas?

Ukuhlolwa komdlavuza wamanyikwe kubaluleke kakhulu emaqenjini alandelayo asengozini enkulu. Noma yisiphi isiguli esidala kuneminyaka engu-18 esina:

• Ukuguqulwa kwe-BRCA

• I-Cystic Fibrosis

• I-Familial Adenomatous Polyposis (FAP)

• I-Familil Atypical Multiple Mole Melanoma (FAMMM)

• I-Hereditary Nonpolyposis Colorectal Cancer (HNPCC) noma i-Lynch Syndrome

• I-Hereditary Pancreatitis

• Ukuguqulwa kwe-PALB2

• I-Peutz-Jeghers Syndrome

• Umlando womndeni womdlavuza wamanyikwe ezihlotsheni ezimbili ze-first degree

Iyini iphrothokholi yokuhlola?

Iziguli zizoba nokubonisana okuphelele noDkt. Ligresti. Bazobe sebehlolwa i-IMMray PanCan-d kanye ne-MRI noma i-EUS. Uma yonke imiphumela isikhona, bazohlangana noDkt. Ligresti ukuze bayibuyekeze kanye nohlelo lokugadwa okuqhubekayo. Lokhu kuvame ukwenziwa minyaka yonke.

Kungani kubalulekile ukutholwa komdlavuza we-pancreatic kusenesikhathi? Izimpawu zivame ukukhula kuphela ngesifo esifika sekwephuzile, ngakho-ke iningi lomdlavuza we-pancreatic litholwa sekwephuzile lapho ukwelashwa kungasebenzi kahle.

Ubani osengozini yokuthola umdlavuza we-pancreatic? Ukuhlonza iziguli ezisengozini yokuthola lesi sifo ngenxa yokuguqulwa kwezakhi zofuzo okwaziwayo noma umlando womndeni womdlavuza wama-pancreas kungaba semqoka ekuwutholeni kusenesikhathi. Amaqembu amancane asengozini enkulu amelela ingxenye enkulu yazo zonke izimo zomdlavuza wamanyikwe.

Ngabe lolu hlolo olusha lusebenza kanjani? I-IMMray PanCan-d ihlaziya ama-biomarker angu-9 ku-serum ukuze ithole i-pancreatic ductal adenocarcinoma (PDAC), uhlobo oluvame kakhulu lomdlavuza we-pancreatic. Ama-biomarker ahilelekile ezinqubweni eziningi zamaselula okuhlanganisa i-metabolism, ukuvuvukala nokulimala / ukulungiswa kwezicubu, kanye ne-CA19-9, kufakiwe ekuhlolweni. Impendulo yesampula ku-biomarker ngayinye iyalinganiswa bese ihlanganiswa kusetshenziswa i-algorithm ukuze kutholwe umphumela wokuhlola "Isiginesha Enengozi Ephezulu", "Ayinayo Isiginesha Yengozi Ephezulu", noma "Umugqa Womngcele".

Ukusebenza Kokuhlola: Encwadini yakamuva ebuyekezwe ontanga kaBrand et al eshicilelwe ku-Clinical and Translational Gastroenterology, ukuhlolwa kwe-IMMray PanCan-d kubonise ukuzwela okungama-92% nokucaciswa okungu-99% ekutholeni i-pancreatic ductal adenocarcinoma (PDAC) kusetshenziswa i-serum. Uhlolo lwe-IMMray PanCan-d lukwazile ukuthola i-Stage I & II PDAC enokuzwela okungu-89% nokucaciswa okungu-99%.

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Isithombe sikaLinda Hohnholz

Linda Hohnholz

Umhleli omkhulu we eTurboNews ezinze eTN HQ.

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