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Ucwaningo Olusha Lokuhlola Isifo I-Alzheimer's

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I-Seelos Therapeutics, Inc., inkampani ye-biopharmaceutical esesiteji somtholampilo egxile ekuthuthukisweni kwezindlela zokwelapha ukuphazamiseka kwesistimu yezinzwa kanye nezifo ezingavamile, namuhla imemezele ukuthi ithole incwadi yokuvuma ye-Clinical Trial Notification (CTN) evela eMnyangweni Wezempilo Kahulumeni wase-Australia. I-Therapeutic Goods Administration (TGA) yocwaningo lomshayeli lwe-SLS-005 (umjovo we-trehalose, 90.5 mg/mL wokufakwa emthanjeni) wokwelapha iziguli ezinesifo i-Alzheimer's. 

“Umsebenzi we-Trehalose ku-Alzheimer's uhlukile njengoba uvimbela kokubili i-beta-amyloid pathology kanye nezibalo ze-tau kumamodeli wamagundane angaphambi kwekliniki. Lo msebenzi ubonakala wenziwe nge-intraneuronal, owenzeka ngaphakathi kweseli, ohlukile ekwelashweni okugxile kumasosha omzimba. Kokubili iphrotheni eyandulela i-amyloid kanye nama-oligomers e-tau ayi-cytoplasmic ngaphakathi kweseli futhi angenziwa yi-Trehalose ngokwenza i-autophagy kanye nezinhlelo ze-proteasomal. I-Autophagy iye yathinteka ekulimazeni amanye amaphrotheni ahlanganiswe ngendlela engafanele,” kusho uRaj Mehra Ph.D., uSihlalo kanye ne-CEO yeSeelos. "Silindele ukuthola ubufakazi kanye nemininingwane ebalulekile mayelana nokufaneleka kwe-SLS-005 ekwelapheni lezi zimo zemizwa, ezilimaza kakhulu iziguli nemindeni yazo ngokomzimba, ngokomzwelo nangokwezimali."            

Ngaphezu kwalokho, u-Seelos uthole ukugunyazwa ukwenza ucwaningo lwebhasikidi olulebula elihlukile (ACTRN: 12621001755820) e-Australia ukuze kuhlolwe ukusebenza kwe-SLS-005 ekuqhubekeleni phambili kwesifo nokuqina, kanye nokuphepha nokubekezelelana kwayo, kubahlanganyeli abanezifo ezikhethiwe ze-neurodeergenerative. kuhlanganise nesifo sikaHuntington.

Umkhandlu olawulayo wase-Australia wezivivinyo zemitholampilo, i-TGA, kanye Nesikhuthazo Sentela Yocwaningo Nentuthuko sikahulumeni wase-Australia sinikeza ithuba elihle kakhulu ezinkampanini ezincane ze-biotech zase-US ukuthi ziqale izivivinyo zemitholampilo e-Australia ngomzamo wokusheshisa ukuqaliswa kwezifundo nokusebenzisa imitholampilo eqinile yezwe. amakhono esilingo.

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umhleli

Umhleli omkhulu we-eTurboNew nguLinda Hohnholz. Uzinze e-eTN HQ e-Honolulu, e-Hawaii.

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