Ngokusho kwe-ADx Health, "Ngokumangalisayo, abantu babelana ngo-99% wekhodi efanayo yofuzo. I-1% ehlukile ihlanganisa izinguquko ezisekelweni ezithile ze-nucleotide, okuholela ekushintsheni kwezakhi zofuzo ezithile, futhi kwezinye izimo, izinguquko ezingozini zezifo ezithile,” okuhlanganisa ingozi yesifo i-Alzheimer's.
Manje sekwamukelwa kabanzi ukuthi isifo se-Alzheimer sibangelwa kokubili okuguquguqukayo (njengokudla okunempilo, ukuvivinya umzimba, ukulala) kanye nezingaguquleki (ufuzo, ubudala, ubulili) izici zengozi. Nakuba i-APOE iyisici sofuzo esaziwa kakhulu esihlotshaniswa nobungozi besifo i-Alzheimer's, i-GenoRisk polygenic test ihlola izakhi zofuzo ezingama-29 ngaphezu kwe-APOE.
Kodwa-ke, ucwaningo oluningi luke lwasebenzisa kuphela ingozi yofuzo ye-APOE ekuhloleni izifundo, okushiya izikhala ezinkulu ekuqondeni isithombe esigcwele sokubikezela ingozi ye-AD, yingakho i-ADx Health ithuthukise indlela entsha yokuhlola i-Alzheimer's ngokuhlolwa kwe-GenoRisk.
Idatha yocwaningo lwe-GenoRisk ikhombisa ukuthi kungaba nebanga elibanzi lezingozi ngaphakathi kwe-APOE genotype ethile. Kwezinye izimo, abantu abanobungozi obuncane be-APOE bangase babe sengozini enkulu yofuzo kunomuntu onokwehluka kwe-APOE okuyingozi kakhulu ngenxa yokufakwa kweminyaka yobudala nokulungiswa kobulili.
"Ngokuqonda kangcono ukuthi izakhi zofuzo eziningi zisebenzisana kanjani ekubikezeleni ingozi ye-AD, lolu hlobo lokuhlola i-polygenic lunganikeza ukuqonda okukhulu ekuphathweni komuntu ngamunye kwe-Alzheimer, okuhlanganisa indlela iziguli eziphathwa ngayo, iziphetho zokuhlolwa kwemitholampilo, kanye nezinyathelo zokunciphisa ubungozi", kusho uRyan Fortna. , MD, omunye wababhali bocwaningo.
