Ukulimala Kweseli Lobuchopho Kuphakeme Ezigulini ze-COVID-19 kuneziguli ze-Alzheimer's

Okubalulekile, umbiko wamanje, oshicilelwe ku-inthanethi ngoJanuwari 13 ku-Alzheimer's & Dementia: The Journal of the Alzheimer's Association, wenziwe ngaphezu kwezinyanga ezimbili ngaphambi kwalolu bhubhane (Mashi-Meyi 2020). Noma ikuphi ukuzimisela kokuthi iziguli ezine-COVID-19 zisengozini eyengeziwe yesifo i-Alzheimer's esizayo, noma esikhundleni salokho zilulame ngokuhamba kwesikhathi, kufanele zilinde imiphumela yezifundo zesikhathi eside.

Liholwa abacwaningi e-NYU Grossman School of Medicine, ucwaningo olusha lwathola amazinga aphezulu amamaki ayisikhombisa okulimala kobuchopho (neurodegeneration) ezigulini ze-COVID-19 ezinezimpawu zemizwa kunalezo ezingenazo, kanye namazinga aphezulu kakhulu ezigulini ezishonele esibhedlela kunalezo. kulabo abakhululwa futhi babuyiselwe ekhaya.

Ukuhlaziywa kwesibili kutholwe ukuthi isethi encane yezimpawu zomonakalo ezigulini ezilaliswe esibhedlela ezine-COVID-19, esikhathini esifushane zaziphezulu kakhulu kuneziguli ezitholwe zinesifo i-Alzheimer's, futhi kwesinye isikhathi ziphakeme ngokuphindwe kabili. 

"Okutholakele kwethu kusikisela ukuthi iziguli ezilaliswe esibhedlela ngenxa ye-COVID-19, ikakhulukazi lezo ezinezimpawu zemizwa ngesikhathi sokutheleleka okukhulu, zingase zibe namazinga ezimpawu zokulimala ebuchosheni aphakeme, noma aphakeme kunalawo abonwa ezigulini ezinesifo i-Alzheimer's," kusho umbhali oholayo u-Jennifer A. Frontera, MD, uprofesa eMnyangweni Wezezinzwa e-NYU Langone Health. 

Isakhiwo Sokufunda/Imininingwane                                                    

Ucwaningo lwamanje lukhombe iziguli ezingama-251 ukuthi, yize zineminyaka engama-71 ngokwesilinganiso, zazingenalo irekhodi noma izimpawu zokuncipha kwengqondo noma ukuwohloka komqondo ngaphambi kokulaliswa esibhedlela ngenxa ye-COVID-19. Lezi ziguli zabe sezihlukaniswa ngamaqembu anezimpawu zemizwa nezingenazo ngesikhathi sokutheleleka nge-COVID-19, lapho iziguli zilulama futhi zakhishwa, noma zishona.

Ithimba labacwaningi nalo, lapho kungenzeka khona, liqhathanise amazinga omaka eqenjini le-COVID-19 neziguli ezise-NYU Alzheimer's Disease Research Center (ADRC) Clinical Core cohort, ucwaningo oluqhubekayo, lwesikhathi eside e-NYU Langone Health. Asikho kulezi ziguli eziyi-161 ezilawulayo (ezingama-54 ngokwengqondo evamile, ezingama-54 ezinokukhubazeka okulinganiselwe kwengqondo, kanye nezingu-53 ezitholakale zinesifo i-Alzheimer's) ezazine-COVID-19. Ukulimala kobuchopho kukalwe kusetshenziswa ubuchwepheshe be-molecule eyodwa ye-array (SIMOA), engalandelela amazinga egazi amaminithi ama-neurodegeneration marker kuma-piccogram (ingxenye eyodwa yesigidintathu segremu) ngemililitha ngayinye yegazi (pg/ml), lapho ubuchwepheshe obudala bungakwazi khona.

Omaka abathathu bocwaningo - i-ubiquitin carboxy-terminal hydrolase L1 (UCHL1), i-tau isiyonke, i-ptau181 - yizinyathelo ezaziwayo zokufa noma zokukhubaza ama-neurons, amangqamuzana avumela imizila yezinzwa ukuthwala imilayezo. Amazinga we-neurofilament light chain (NFL) akhuphuka ngomonakalo kuma-axon, izandiso zama-neurons. I-Glial fibrillary acidic protein (GFAP) isilinganiso somonakalo kumaseli e-glial, asekela ama-neurons. I-Amyloid Beta 40 kanye ne-42 amaprotheni aziwa ukuthi akheke ezigulini zesifo i-Alzheimer's. Imiphumela yocwaningo lwangaphambilini iphikisa ngokuthi i-tau ephelele kanye ne-phosphorylated-tau-181 (p-tau) nazo ziyizinyathelo eziqondile zesifo i-Alzheimer's, kodwa indima yazo kulesi sifo iseyimpikiswano. 

Omaka begazi eqenjini lesiguli se-COVID balinganiswa ngeserum yegazi (ingxenye yoketshezi lwegazi eye yenziwa ukuthi ihlule), kuyilapho lezo ezisocwaningweni lwe-Alzheimer zikalwa nge-plasma (ingxenyana yegazi ewuketshezi esala lapho ukujiyisa kuvinjelwa). Ngenxa yezizathu zobuchwepheshe, umehluko usho ukuthi amazinga e-NFL, GFAP, kanye ne-UCHL1 angafaniswa phakathi kweqembu le-COVID-19 neziguli ocwaningweni lwe-Alzheimer, kodwa isamba se-tau, i-ptau181, i-Amyloid beta 40, ne-amyloid beta 42 zingaqhathaniswa kuphela ngaphakathi. iqembu leziguli ze-COVID-19 (izimpawu ze-neuro noma cha; ukufa noma ukukhishwa).

Ngaphezu kwalokho, isilinganiso esiyinhloko somonakalo wezinzwa ezigulini ze-COVID-19 kwakuyi-toxic metabolic encephalopathy, noma i-TME, enezimpawu ukusuka ekudidekeni kuya ekuqulekeni, futhi okubangelwa ngesikhathi sokutheleleka okunzima ubuthi obukhiqizwa njengoba amasosha omzimba esabela ngokweqile (sepsis), izinso ziyahluleka (uremia) , futhi ukulethwa komoyampilo kusengozini (hypoxia). Ngokuqondile, isilinganiso samaphesenti akhuphuka emazingeni amakaki ayisikhombisa eziguli ezisesibhedlela ezine-TME uma kuqhathaniswa nalabo abangenazo izimpawu ze-neurological (umdwebo 2 ocwaningweni) kwakungamaphesenti angu-60.5. Kwabamaka abafanayo eqenjini le-COVID-19, ukukhuphuka kwamaphesenti amaphakathi uma kuqhathaniswa nalabo abakhishwe ngempumelelo ekhaya esibhedlela nalabo abashonele esibhedlela bekungamaphesenti ayi-124.

Iqoqo lesibili lokutholakele liqhathaniswe namazinga e-NFL, GFAP kanye ne-UCHL1 ku-serum yeziguli ze-COVID-19 ngokumelene namazinga omaka abafanayo ku-plasma yeziguli ezingezona i-COVID Alzheimer's (umfanekiso 3). I-NFL ibingaphezu kwesikhathi esifushane ngamaphesenti angama-179 (i-73.2 iqhathaniswa nama-26.2 pg/ml) ezigulini ze-COVID-19 kuneziguli ze-Alzheimer's. I-GFAP yayiphezulu ngamaphesenti angama-65 (i-443.5 iqhathaniswa nama-275.1 pg/ml) ezigulini ze-COVID-19 kuneziguli ze-Alzheimer, kuyilapho i-UCHL1 yayiphakeme ngamaphesenti ayi-13 (43 iqhathaniswa nama-38.1 pg/ml).

“Ukulimala okubuhlungu kobuchopho, okubuye kuhlotshaniswe nokwenyuka kwalezi zimpawu eziphilayo, akusho ukuthi isiguli sizoba ne-Alzheimer's noma ukuwohloka komqondo okuhlobene kamuva, kodwa kwandisa ingozi yako,” kusho umlobi omkhulu uThomas M. Wisniewski, MD, i UGerald J. kanye noDorothy R. Friedman USolwazi eMnyangweni Wezezinzwa kanye nomqondisi weSikhungo Sezinzwa Zengqondo e-NYU Langone. "Ukuthi lobu budlelwano bukhona yini kulabo abasinda ku-COVID-19 kunzima kuwumbuzo okufanele siwuphendule ngokuqhubekayo nokuqapha lezi ziguli."

Kanye noDkt. I-Fronter ne-Wisniewski, ababhali be-NYU Langone Health bahlanganisa umbhali wokuqala u-Allal Boutajangout, u-Arjun Masurkarm, u-Yulin Ge, u-Alok Vedvyas, uLudovic Debure, u-Andre Moreira, u-Ariane Lewis, uJoshua Huang, u-Sujata Thawani, u-Laura Balcer, no-Steven Galetta. Futhi umbhali kwakunguRebecca Betensky e-New York University School of Global Public Health. Lolu cwaningo luxhaswe uxhaso lweNational Institute on Aging COVID-19 administrative supplement 3P30AG066512-01.