UKUKHULUMA
Ukudluliswa okuphezulu kwe-SARS-CoV-2 kuyenzeka eChile yize kunomkhankaso omkhulu wokugoma, othembele kakhulu emuthini wokugoma ongasebenzi we-Sinovac Biotech kanye nokuncane emuthini wokugoma we-mRNA ovela ePfizer / BioNTech kanye nemithi yokugoma ye-virus engaphenduki I-Oxford / AstraZeneca neCansino Biologicals.
Ukuhlinzwa kokugcina okubikwe ezweni kugqugquzelwe ukuhlukahluka kwe-SARS-CoV-2 i-Gamma ne-Lambda, okuke kwachazwa njengokuhlukile okukhathazayo ezinyangeni ezimbalwa ezedlule kanti lokhu kwakamuva kusanda kwamukelwa njengokuhlukile kwe-WHO. Ngenkathi okuhlukile kwe-Gamma kunoshintsho oluyi-11 kuphrotheni ye-spike okuhlanganisa nalezo ezikusizinda sokubopha i-receptor-binding (RBD) okuhlotshaniswa nokwenyuka kokubophezela kwe-ACE2 kanye nokutheleleka (N501Y) noma ukuphunyuka komzimba (K417T kanye ne-E484K) iphrotheni ye-spike yokwehluka kwe-Lambda inokuhluka okuhlukile. iphethini yezinguquko ezingu-7 (Δ246-252, G75V, T76I, L452Q, F490S, D614G, T859N) lapho i-L452Q ifana nokuguqulwa kwe-L452R okubikwe kwehlukile kwe-Delta ne-Epsilon.
Ukuguqulwa kwe-L452R kukhonjisiwe ukuthi kunikeze ukuphunyuka kwamagciwane kuma-antibody monoclonal (mAbs) kanye ne-plasma yokululama.
Ngaphezu kwalokho, ukuguqulwa kwe-L452R kukhonjisiwe futhi ukwandisa ukwanda kokutheleleka ngegciwane futhi idatha yethu iphakamisa ukuthi ukuguqulwa kwe-L452Q okukhona okuhlukile kweLambda kungahle kunikeze izakhiwo ezifanayo nalezo ezichazwe i-L452R. Kuyathakazelisa ukuthi ukususwa okungu-246-252 kusizinda se-N-terminal (NTD) seLambda Spike kutholakala endaweni ephezulu ye-antigenic ngakho-ke, lokhu kususwa nakho kungasiza ekuphunyukeni komzimba. Ngaphezu kwalokho, ukuguqulwa kwe-F490S nakho kuhlotshaniswe nokubalekela kuma-sera wokululama.
Ngokuhambisana nalezi zinto ezingaphikiswa, imiphumela yethu ikhombisa ukuthi iphrotheni ye-spike yohlobo lweLambda inika ukuphunyuka kwamagciwane ekunciphiseni amasosha omzimba atholwe umuthi wokugoma weCoronaVac. Ukuthi ngabe ukwahluka kweLambda kuphunyukelani nempendulo yeselula ekhonjiswe ukuthi yaphakanyiswa yiCoronaVac akukaziwa.
Siphinde sabona ukuthi iphrotheni ye-spike yokuhluka kweLambda iveze ukwanda kokungalingani uma kuqhathaniswa ne-spike protein yezinhlobonhlobo ze-Alpha neGamma, zombili ezinokubikwa kokutheleleka nokusabalalisa.
Ngokubambisana, idatha yethu ikhombisa okokuqala ukuthi ukuguqulwa okukhona kuphrotheni ye-spike yeLambda okuhlukile kunikeza ukuphunyuka ekunciphiseni amasosha omzimba nokwanda kokutheleleka. Ubufakazi obethulwe lapha buqinisa umqondo wokuthi imikhankaso emikhulu yokugoma emazweni anamazinga aphezulu okusabalalisa we-SARS-CoV-2 kumele ahambisane nokuqapha okuqinile kwe-genomic okuhlose ukukhomba ngokushesha izihlukanisi zegciwane ezintsha ezithwala ukuguqulwa kwama-spike kanye nezifundo ezihlose ukuhlaziya umthelela walokhu ukuguquka kwezinguquko ekuphunyukeni kwamasosha omzimba kanye nokuqhamuka kwemigomo.
I-COVID-19 ithuthuka ngokushesha. Lokhu kungabonakala eHawaii lapho izinombolo zaziphansi futhi zeqa ukurekhoda okuphezulu ngezokuvakasha ezikhulayo.
