I-New Digital Pathology Ithola Isifo sika-Parkinson Sasekuqaleni

I-PreciseDx, esanda kuphuma e-Mount Sinai Health System eNew York, NY, ukuphela kwenkampani yeCancer Risk Stratification ehlinzeka ngolwazi lwengozi oluqondene nesiguli ngokuhlaziya izici ze-morphology. Le nkampani namuhla imemezele ubuchwepheshe bayo be-digital pathology obunikwe amandla yi-AI bungaxilonga ngokunembile isifo sikaParkinson (PD) ezigulini eziphilayo ngaphambi kokuqala kwezimpawu ezinzima.

Ukuhlonza isifo sika-Parkinson kuyinselele kuzo zonke izigaba ngenxa yezimpawu eziguquguqukayo, ukugula okuhambisana nakho, kanye nezimo zokulingisa, ukuxilongwa okuqinisekile okuza ngemuva kokuhlolwa kwesidumbu. Lolu cwaningo oluyisisekelo lwathola ukuthi ubuchwepheshe be-PreciseDx obunikwe amandla yi-AI buyakwazi ukusiza ukuhlonzwa okuphelele kwe-Parkinson, okuhlinzeka ngolwazi olubalulekile lokwelashwa kwangaphambili.

"Lokhu okutholakele kubonisa amandla obuchwepheshe ukusiza ekuxilongweni kwesifo sikaParkinson," kusho uJamie Eberling, PhD, iPhini Likamongameli Omkhulu Wezinsiza Zokucwaninga e-Michael J. Fox Foundation for Parkinson's Research (MJFF). "Amathuluzi okuxilonga ayinhloso, ikakhulukazi ekuqaleni kwesifo, abalulekile ekuqhubekiseni izinqumo zokunakekelwa kanye nokuklama izivivinyo ezibheke ekwelashweni nasekulapheni okungcono."

I-MJFF ixhase ngokwengxenye ukuhlaziya kwe-AI futhi yaxhasa ucwaningo olunikeze idatha (i-Systemic Synuclein Sampling Study).

Ucwaningo lwe-PreciseDx lwasebenzisa ama-algorithms enkampani e-AI (i-Morphology Feature Array™) ukuze kutholwe i-IHC ye-α-synuclein ngaphakathi kwemizwa eseceleni yezindlala zamathe [okungukuthi, i-peripheral Lewy-type synucleinopathy (LTS)], kanye nokukhipha isici sobuningi kusetshenziswa izici ze-morphology ukuze ukuhlukanisa ngokunembile i-LTS kumasampula e-biopsy yesifo sika-Parkinson ngokusekelwe esichasiselweni se-pathologist samasampuli okuqeqesha. Ngemva kokuqeqeshwa, ukuhlolwa kwe-algorithmic kwaqinisekiswa kusetshenziswa isethi ehlukile yezibonelo ze-biopsy eziqinisekisiwe.

I-PreciseDx's AI Morphology Feature Array ikwazile ukuthola ukugula kuka-Parkinson kuma-patches ezithombe kusuka kumasampuli e-biopsy anozwela angu-99% kanye nokucaciswa okungu-99% uma kuqhathaniswa neqiniso lesisekelo lesichasiselo. I-AI ikhiphe udokotela wezifo zabantu ngokunemba okungu-0.69 uma kuqhathaniswa no-0.64 ekubikezelweni kwesimo sesifo sika-Parkinson sasemtholampilo.

Indlela ye-MFA ye-PreciseDx yokufaka isizinda nokuhlaziya yenza ama-algorithms amasha athuthukiswe futhi aqinisekiswe ngokumelene neziphetho zomtholampilo. Lokhu kubaluleke kakhulu ukudala izivivinyo ezintsha zokuxilonga, ukuxilongwa okunembile nokuphindaphindayo, ukubikezela, ukukhetha kwesiguli ukwelashwa kwezimo ezihlukahlukene.

"Ngokwesiko, amasistimu wokulinganisa i-pathology abheka izakhi ezimbalwa ze-morphology ukwenza ukuxilongwa. Ngokungafani nanoma iyiphi indlela yokubala egunyazwe umuntu, i-PreciseDx's AI Morphology Feature Array (MFA) ingahlola izinkulungwane zezici ezihlukene futhi ikhulise lobo budlelwano phakathi kwabo,” kusho uJohn F. Crary, MD-PhD, uProfesa eminyangweni ye-Pathology, Neuroscience, kanye ne-Artificial Intelligence & Human Health e-Icahn School of Medicine eNtabeni iSinayi. "Lolu cwaningo olushintsha imboni lubonise ukuthi sidinga ukuvuselela indlela esicabanga ngayo nge-pathology futhi sincike ekusebenziseni i-AI ukuthola izifo ngokunembe kakhudlwana, njenge-PD. Lokhu kukhanyisa imboni ocwaningweni oluqondile lokuthi i-computational pathology ingaqhubekisela phambili kanjani umuthi mayelana nokuhlonza nokuhlonza izifo ngokunembile. ”

"Sibheke ngabomvu ukusebenzisana ne-PreciseDx njengoba ihlola amandla okusebenzisa isiteji se-AI ku-pathology kuzo zonke izifo eziningi, kuhlanganise ne-Parkinson," kusho u-Erik Lium, PhD, uMongameli, i-Mount Sinai Innovation Partners kanye nePhini Likamongameli Omkhulu kanye ne-Chief Commercial Innovation Officer, I-Mount Sinai Health System.

Ubuchwepheshe bokuhlukanisa ubungozi bomdlavuza busekelwe empahleni yengqondo eyakhiwe ubuhlakani be-Mount Sinai futhi inikezwe ilayisense yakwa-PreciseDx. I-Mount Sinai kanye nophiko lwe-Mount Sinai banentshisekelo yezezimali ku-PreciseDx. I-Mount Sinai iphinde ibe nokumeleleka ku-PreciseDx Board of Directors, okuhlanganisa noDkt. Lium.