Nakuba ikakhulukazi iyisifo sokuphefumula, i-COVID-19 ikhonjiswe ukuthi ibangela uhla lwezimpendulo, okuhlanganisa nemiphumela emibi ohlelweni lwenhliziyo nemithambo yegazi. Ezinye iziguli zibonise ukusabela okuvuthayo okungase kubangele i-thrombosis, futhi kunezehlakalo eziphezulu kulabo abagula kakhulu.
Ephepheni lokuqala, abacwaningi eNyuvesi yasePennsylvania bahlonze abalamuli ababalulekile bokuvuvukala kanye nesifo senhliziyo ezigulini ze-COVID-19 ezihlotshaniswa kahle nokusebenza kweplatelet ohlelweni lwe-BioFlux. Ithimba liphinde labonisa ukuthi i-Syk inhibitor fostamatinib ibuyisele emuva ukusebenza kwe-platelet ocwaningweni lwe-BioFlux. Abacwaningi baphethe ngokuthi lokhu kumelela indlela ehlukile, eqondiwe yokubonisa lo mphumela.
Ephepheni lesibili, abacwaningi baseNyuvesi yaseTuebingen babonise ukuthi amazinga ancishisiwe e-cAMP (cyclic adenosine monophosphate) kumaplatelet andisa ukuhlangana kweplatelet okubangelwa ama-antibody kanye nokwakheka kwe-thrombus. Le miphumela yavinjelwa i-Iloprost, i-ejenti yokwelapha egunyazwe ngokomtholampilo eyandisa amazinga e-intracellular cAMP kumaplatelet.
Womabili la maphepha athembele ohlelweni lwe-BioFlux lokuhlola ukusebenza kweplatelet ezigulini ze-COVID-19. Uhlelo lwe-BioFlux lusebenza “njenge-artery ku-chip” elawula ngokunembile indawo encane yeseli ukuze ilingise izimo emzimbeni womuntu, ihlinzeka ngenkundla ekahle yocwaningo lokusebenza kwegazi oluhlobene ne-COVID-19. Isetshenziswa kumalebhu angaphezu kuka-500 emhlabeni jikelele, uhlelo lwe-BioFlux lutholakala ngezindlela ezihlukahlukene ukuze luhlangabezane nezidingo zohlelo lwanoma iyiphi ilabhorethri. Amasistimu ayatholakala ngamakhono ahlukahlukene kanye nokusebenza kwawo futhi asetshenziswa ocwaningweni oluyisisekelo ngokutholwa kwezidakamizwa nokuthuthukiswa kokuxilonga.
