Ucwaningo oluzimele oluvela eJalimane luqinisekisa ukuthi i-bimodal neuromodulation inganciphisa kakhulu izimpawu ze-tinnitus esimweni somtholampilo somhlaba wangempela.
Inkampani yemishini yezokwelapha yase-Ireland, i-Neuromod Devices Ltd. (Neuromod), yamukele ukutholwa kocwaningo oluzimele olwenziwe e-German Hearing Centre (DHZ) e-Hannover Medical School, ethole ukuthi i-85% yeziguli ze-tinnitus zithole ukuncipha kwezimpawu zabo ze-tinnitus. (kusekelwe kumphumela we-Tinnitus Handicap Inventory[i] kuzo zonke iziguli ezingama-20) uma usebenzisa idivayisi yokwelapha ye-Lenire.
Lolu cwaningo lubonise ukuthi amasonto ayisithupha kuya kwangu-12 okwelashwa kusetshenziswa i-Lenire, idivayisi ye-bimodal neuromodulation eyakhiwe yi-Neuromod enikeza ukukhuthazwa komsindo nogesi wolimi, ingafinyelela ngokuphephile ukuthuthukiswa okunenjongo emtholampilo kubunzima bezimpawu ze-tinnitus esimweni somtholampilo sangempela.
Ucwaningo lwaluholwa uDkt. U-Thomas Lenarz, u-Anke Lesinski-Schiedat, kanye no-Andreas Buechner abavela eMnyangweni we-Otolaryngology e-Hannover Medical School, eJalimane.
Le miphumela isanda kushicilelwa kujenali yesayensi esezingeni eliphezulu, Ukuvuselela Ubuchopho[ii].
Idatha yomhlaba wangempela ihambisana nemiphumela yocwaningo lomtholampilo olukhulu lwe-Neuromod (TENT-A1), olufaka ababambiqhaza abangama-326. Uhlolo lwe-TENT-A1, imiphumela yalo eyashicilelwa ngo-Okthoba 2020[iii], lubonise ukuthi u-86.2% wabahlanganyeli abathobela ukwelashwa babike ukuthuthuka kwezimpawu zabo ze-tinnitus ngemva kwesikhathi esingamaviki angu-12 besebenzisa i-Lenire.
Ucwaningo lwe-Hannover lwaluhilela ubude besikhathi esifushane sokwelashwa (amaviki angu-6-12) futhi lwabona ukuthuthukiswa okulinganiselwe (ukunciphisa) kumaphuzu we-THI wamaphuzu we-10.4, okudlula umehluko obalulekile womtholampilo wamaphuzu we-7. Le datha yomhlaba wangempela evela ocwaningweni lwe-Hannover ihambisana nocwaningo lwe-TENT-A1, olubone ukuthuthukiswa okufanayo ngemva kwamasonto angu-6 okwelashwa futhi lazuza ingqikithi yokuthuthukiswa kwamaphuzu angu-14.6 ngemva kwamasonto e-12 agcwele okwelashwa. Ngaphezu kwalokho, azikho izehlakalo ezimbi ezihlobene nokwelashwa ezibikiwe.
U-Lenire usebenza ngokuletha ama-pulses kagesi athambile olimini, esebenzisa ingxenye yomlomo ebizwa ngokuthi 'Tonguetip', ehlanganiswe nomsindo odlalwa ngama-headphones ukushayela izinguquko zesikhathi eside noma neuroplasticity ebuchosheni ukuze kwelaphe i-tinnitus.
Uhlolo lomtholampilo lwe-TENT-A1, oluhilele ababambiqhaza abangu-326 kulo lonke elase-Ireland naseJalimane, lubonise ukusebenza kahle kuka-Lenire ekuthuthukiseni izimpawu ze-tinnitus zabahlanganyeli. I-86.2% yabahlanganyeli abathobela ukwelashwa babike ukuthuthukiswa kwezimpawu zabo ze-tinnitus ngemva kwesikhathi sokwelashwa samasonto angu-12[iv]. Lapho kulandelwa izinyanga eziyi-12 ngemuva kokwelashwa, u-80.1% wabahlanganyeli abathobela ukwelashwa babe nentuthuko eqhubekayo ezimpawu zabo ze-tinnitus.
Ucwaningo lwe-TENT-A1 lumele uhlolo lomtholampilo olukhulu nolude kakhulu olwalandelwayo olwake lwenziwa emkhakheni we-tinnitus futhi kwakuyindaba ekhava yephephabhuku lesayensi I-Science Translational Medicine ngo-Okthoba 2020.
I-Neuromod igxile kubuchwepheshe be-neuromodulation obungahlanyisi futhi iklame futhi yathuthukisa i-Lenire, esetshenziselwe ukwelapha iziguli ze-tinnitus kusukela ngo-2019.
