Ngokombiko wephephandaba lansuku zonke lase-Italy, i-Il Corriere della Sera, kunezinhlanganisela ezikhona ezimonyweni, ezemithi, nasekudleni okungadala umuthi wokugoma we-COVID kwabanye abantu ngenxa yokuvezwa kwangaphambilini. Into ebangela ukusabela okweqile okwenziwe abanye abantu ngemuva kokuthola i-Pfizer's Umgomo we-covid kungenzeka itholakele. Lokhu kungaba yinhlanganisela ye- "polyethylene glycol", eyaziwa nangokuthi i-PEG.
Inhlanganisela ejwayelekile ezimonyweni
Yize iziphathimandla zezempilo zisaphenya, njengenkampani eyenza imithi uqobo lwayo, siyazi ukuthi i-PEG ingahlotshaniswa ngendlela engajwayelekile nokungezwani komzimba njengoba kuqinisekiswe nguPeter Marks, uMqondisi weCentre for Product Evaluation and Research, US Food and Drug Administration (FDA) imikhiqizo yezinto eziphilayo.
Lokho kusabela kokungezwani komzimba kungahle kujwayeleke kakhulu kunezingajwayelekile kakhulu ezivame ukwenzeka. Le nhlanganisela itholakala kuma-shampoo, okokuxubha amazinyo nakwiminye imikhiqizo eminingi. Abanye abantu bangaba sengozini enkulu ngoba banamazinga aphezulu ama-antibodies ePEG. Kuyo yomibili imigomo, i-Pfizer-BioNTech neModerna, i-PEG iyingxenye yemvilophu enamafutha ezungeze i-messenger RNA, isithako esiyinhloko somuthi wokugoma.
Lapho i-mRNA isingene kumaseli, iyawafundisa ukuthi akhe iprotheni efana ne-spike protein etholakala ebusweni be-coronavirus. Lokhu kubangela ukusabela okuthile komzimba okuqinisa ukuzivikela komzimba lapho kutholakala igciwane langempela. Imvilophu enamafutha equkethe i-PEG isiza ukuqinisekisa ukuthi i-mRNA inqamula ulwelwesi lweseli. I-PEG ayikaze isetshenziswe emuthini wokugoma ovunyelwe ngaphambili, kepha itholakala emithini eminingi. Izifundo emasontweni azayo zizokwenziwa kubantu abanamazinga aphezulu ama-anti-PEG noma abake babhekana nezimpendulo ezinzima zomuthi noma imigomo ngaphambili.
Amacala okusabela okweqile
Ukusabela kwe-Anaphylactic kungenzeka nganoma yimuphi umuthi wokugoma kepha imvamisa kuyivelakancane ngokweqile - kuzungezwe isilinganiso esisodwa ngesilinganiso esisodwa sesigidi. Kusukela ngoDisemba 1, 1, noma kunjalo, i-United States ibone amacala ayi-19 e-anaphylaxis phakathi kwabantu abangama-2020 abathole umuthi wokugoma kanti i-United Kingdom inamacala amabili ezifundweni zeSigaba 6 ezaholela ekwamukelweni kwemigomo abantu ababengafakwanga kuyo. Ngomlando wokungezwani komzimba nezakhi zomuthi wokugoma, iqembu elincane labantu, ngakho-ke, kungenzeka ukuthi belimelwe kancane.
Inani elikhulayo lemikhiqizo ye-biopharmaceutical ifaka ama-PEGs. Ngokusho kocwaningo lwango-2016 olwenziwe e-University of North Carolina, eChapel Hill, abantu abangu-72% okungenani banamasosha omzimba athile kuma-PEGs, mhlawumbe ngenxa yokuchayeka ezimonyweni nakwemithi yokwelapha. Cishe i-7% inezinga elingaphakama ngokwanele ukubabeka engcupheni yokuphendula kwe-anaphylactic.
Izincomo
Azisekho iziqiniseko kodwa okucatshangelwayo kuphela: abanye ososayensi bayaqaphela ukuthi inani le-PEG emithini yokugoma ye-mRNA liphansi kunaleli elitholakala emithini eminingi. Okwamanje, kusacutshungulwa ezinye izindlela ze-PEG, kepha umkhankaso wokugoma awumi, futhi ngoba izinzuzo zidlula izingozi futhi bonke labo abathintekayo ngenxa yokungezwani komzimba sebethole.
Imihlahlandlela evela ku- Izikhungo Zokulawula Nokuvimbela Izifo (CDC) eU.SA. Kunconywa ukuthi unganiki imishanguzo yePfizer noma iModerna kunoma ngubani onomlando wokuzwela komzimba kunoma iyiphi ingxenye yomuthi wokugoma. Akunasizathu sokuthi kungani abantu abanomlando wokuphendula okuncane noma okunzima kokudla, izilwane ezifuywayo, imishanguzo yomlomo, noma i-allergen yemvelo akufanele bathole umuthi wokugoma i-CDC uthi. Futhi abantu abangahle babe sengozini enkulu yokuphendula nge-anaphylactic kufanele bahlale endaweni yokugoma imizuzu engama-30 ngemuva kokujova (hhayi nje i- "canonical" 15).
I-COVID, “okuhlukile kwesiNgisi,” iseLombardy: kukhonjwe amacala amabili okuqala
Ukuhluka kwe-coronavirus kukhonjwe nguSan Matteo wasePavia. Okuthiwa “okuhlukile kwesiNgisi” kwe-Sars-CoV-2 coronavirus, igciwane elibhekele i-COVID, nalo likhonjwe eLombardy. Lezi zindaba zihlinzekwa yiPolislinico San Matteo ePavia.
Amacala amabili okuqala ayizakhamizi ezimbili zase-Italy ezafika eMalpensa ezinsukwini ezisanda kwedlula - ngoDisemba 2 no-23. Izenzakalo ezi-24, kuchaza isibhedlela, "azimele zodwa futhi azihlobene nakancane nokuqubuka kwalesi sifo."
Amasampuli ahlolwe enesifo se-swab yamangqamuzana athunyelwe yi-ATS Insubria ku-IRCCS Policlinico San Matteo Foundation ePavia lapho ithimba likaSolwazi Fausto Baldanti lenze khona ukulandelana.
Okubizwa ngokuthi "okuhlukile kwesiNgisi" kukhonjwe ezinsukwini zakamuva ezifundeni ezahlukahlukene zase-Italy (eLazio, Abruzzo, Campania, Veneto, Marche, nasePuglia), futhi kungenzeka ukuthi isivele isabalele nakwezinye izindawo kanye nezwe lonke insimu.
Ngokuya ngocwaningo olutholakalayo njengamanje kanye nochwepheshe ababuye baxoxwa yiCorriere della Sera, lokhu okuhlukile kunamandla okusabalalisa angaba ngaphezulu (aze afike kuma-70%). Abukho ubufakazi bokuthi iyingozi kakhulu noma iyabulala, nokuthi ingamelana nemithi yokugoma evunyelwe noma ivunyelwe ngokumelene ne-COVID.
Akucaci noma okwahlukahluka kwaqhamuka eGreat Britain, kodwa-ke, kuyakhonjwa lapho futhi kwaba yikhona okubusa kakhulu eningizimu mpumalanga yezwe. Phakathi kokuqagela kwemvelaphi yayo, i-European Center for the Surveillance of Infectious Diseases icaphune ukuthi kungenzeka ukuthi yavela esigulini esasicindezelwe ukuzivikela ezifweni, esasingenwe yileli gciwane, saba nesikhathi eside ngaphambi kokululama, sancamela ukuqoqwa kwezinguquko eziningi ezincane.
Ngenxa yokusabalala kwayo, uhulumeni waseBrithani wethule izindlela ezinzima kakhulu zokuvala ngempelasonto edlule. I-European Union yona isithathe izinyathelo zokunciphisa ukuhamba phakathi kweGreat Britain namazwe e-EU kube kuncane kakhulu.
Amacala ama-2 abikwe yiPolislinico San Matteo akhonjwa ngemuva kokusebenza kwale mithetho.
NgoDisemba 26, 2020, iJapan yanquma ukuvala imingcele yayo kubantu bakwamanye amazwe kuze kube nguJanuwari 31, 2021, ngemuva kokukhonjwa kohlobo olusha "lwesiNgisi" kwabanye abagibeli abafika bevela eGreat Britain.
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