I-Nova Mentis Life Science Corp. imemezele ukuthi iluphothule ngempumelelo ucwaningo lwe-oral microdose psilocybin, elabhorethri kaDkt. Viviana Trezza, e-Rome Tre University, e-Rome, e-Italy. Imiphumela idlule konke obekulindelekile ngokuthola ukuthi umthamo ophansi kakhulu we-psilocybin yobunikazi beNkampani iguqule kakhulu iziphambeko zokuziphatha nezokuqonda, njengenkumbulo yokuqashelwa, kumodeli yofuzo ye-X syndrome entekenteke (FXS).
“Ithimba lesayensi eliholwa uDkt. Hausman, kanye noDkt. Viviana Trezza wase-Roma Tre University, bayaqhubeka nokuletha imiphumela ethembisayo yokwelashwa. Isethi yakamuva yedatha ye-microdose yomlomo ayigcini nje ngokuqinisekisa kodwa yeqa imiphumela yethu yokuqala yomjovo,” kusho u-Will Rascan, oyi-CEO ye-NOVA. "Imininingwane ecacile ibalulekile njengoba silungiselela ukuhambisa isicelo sethu sesilingo somtholampilo ku-Health Canada ukuze senze ucwaningo lweSigaba 2A oluhlola ukwelashwa kwe-psilocybin microdose ye-X syndrome ebuthakathaka."
I-Autism spectrum disorder (ASD) yisifo esiyinkimbinkimbi se-neurodevelopmental okungekho ukwelashwa okukhona kuso. I-Fragile X syndrome (FXS) iwuhlobo oluvame kakhulu lokukhubazeka ngokomqondo okuzuzwe njengefa kanye nembangela evame kakhulu ye-monogenic ye-ASD (1). Inhloso yocwaningo lwamanje bekuwukuhlola imithamo ehlukahlukene yomlomo ye-psilocybin yobunikazi benkampani kumodeli yegundane ye-FXS. Umbuzo omkhulu okufanele uphendulwe kulolu cwaningo lwangaphambi komtholampilo bekuwukuthi ingabe ukwelashwa nge-microdose kungaba yindlela yokwelashwa ekhethwayo ku-ASD, uma kuqhathaniswa nokwelashwa kwe-macrodose yomthamo owodwa okuhambisana ne-hallucinogenic neminye imiphumela engemihle.
Ukusebenza kwe-Psilocybin kwahlolwa ku-FXS, ngegundane le-Fmr1 knock-out (Fmr1 KO) (Fmr1-Δexon 8) - imodeli yofuzo esunguliwe ye-FXS (1). Ukulawulwa kohlobo lwasendle kanye nezilwane ze-Fmr1 KO zalashwa ngo-0.1 mg/kg kanye no-0.3 mg/kg we-psilocybin yomlomo njalo ngemva kolunye usuku ekwelapheni okungu-6, esikhathini esingamaviki angu-2, nangosuku lwe-18 kwenziwa ukuhlolwa kokuqashelwa kwento. Sibe nemiphumela emihle kakhulu! Kokubili u-0.1 kanye no-0.3 mg/kg kusebenze kahle ekubuyiseleni ukukhubazeka kwengqondo okuboniswe izilwane ze-Fmr1 KO. Ngaphezu kwalokho, i-0.1 mg/kg isebenze kahle kakhulu, futhi ayizange ibe nemiphumela emibi ebonakalayo. Umthamo we-0.1 mg/kg egundaneni uhumusha cishe ku-1.5 mg umthamo womlomo kumuntu ongu-70 kg.
“Ngijabule ngokukwazi ukubika emphakathini wezokwelapha ukuthi ekugcineni kungenzeka ukuthi sesivule umnyango wokwelashwa kwe-ASD, isidingo esingahlangatshezwanga sezokwelapha esinomthelela omubi esigulini, emndenini nasemphakathini,” kusho uMarvin S. Hausman MD, uSihlalo webhodi le-NOVA's Scientific Advisory. "Imodeli yamagundane esiyisebenzise ilingisa izici ezibalulekile ezifana ne-autistic kubantu futhi imiphumela yocwaningo isekela kakhulu indima ebalulekile yokwelashwa kwe-microdose
I-FXS. Ngaphezu kwalokho, le mpendulo enhle kugundane lazo zonke izinsuku zomlomo we-psilocybin engu-0.1 mg/kg, okulingana cishe nomthamo we-1.5 mg kumuntu ongu-70 kg, kungase kube indlela yokwelapha ekhethwayo yokuguqula izinguquko zokuziphatha kanye nokukhubazeka kwengqondo, futhi mhlawumbe ube nokuphazamiseka kwengqondo. impendulo ye-neuroplastic yesikhathi eside eyakhayo ebuchosheni ngaphandle kwesidingo semithamo emikhulu yezidakamizwa ze-psychedelic ezinemiphumela emibi eyingozi ye-hallucinogenic. "
