I-Entrinsic Bioscience (EBS) imemezele ithuluzi lokulinganisa ukuvuthwa kwamathumbu okungase kuholele ekuthuthukisweni kwama-ejenti okwelapha ukuqunjelwa, okuhlanganisa i-Irritable Bowel Syndrome-Constipation (IBS-C). Umcwaningi waseNyuvesi yaseFlorida uDkt. Sadasivan Vidyasagar, umsunguli nosihlalo webhodi labaluleki besayensi yenkampani, muva nje wabelane ngethuluzi lokulinganisa kangcono i-peristalsis kanye nokusebenzisana kwengcindezi ye-intraluminal, ukufinyela kwemisipha, kanye nezinguquko zevolumu yoketshezi engqungqutheleni ye-Experimental Biology 2022 ebibanjelwe Philadelphia.
I-Peristalsis iyinqubo ehlangene yokufinyela kwemisipha yamathumbu ehambisa ukudla ngomgudu wamathumbu. Nakuba sekufundwe kabanzi, ukuhlaziya ikhwalithi ye-peristaltic propulsion akuqondwa ngokugcwele ngoba alikho ithuluzi eliqinisekile elikhona. Ukushoda kwethuluzi kunomkhawulo wokutholwa kwezidakamizwa emkhakheni wokuqunjelwa, okubandakanya i-IBS-C.
U-Vidyasagar nethimba lakhe, elihlanganisa abacwaningi abavela ku-UF kanye ne-Entrinsic Bioscience, basebenzise ukukhanya okuqondisayo, ukuthwebula izithombe zenkundla kanye nokurekhodwa kwengcindezi ukuze balinganise umsebenzi we-peristaltic.
U-Stephen J Gatto, usihlalo kanye no-CEO we-Entrinsic Bioscience, uhalalisele u-Anusree Sasidharan kanye nalo lonke ithimba likaDkt. Vidyasagar ngokuqhubeka nokuzibophezela kwabo ekushayeleni izindlela ezintsha zokuhlola umgudu wamathumbu.
“Isethulo seqembu sigqamisa ikhono lethu lokulinganisa kangcono i-gut peristalsis futhi sibeka indlela yemithi yokwelapha yesikhathi esizayo engabhekana nokuqunjelwa okungapheli okubangelwa i-opioid kanye nendlela engasekelwe ku-PEG yokuqunjelwa okunamandla kanye ne-IBS-C. Ukungajwayelekile kwe-gut peristalsis kuyisisekelo sezimo eziningi zokwelapha ezijwayelekile, njengokuqunjelwa kanye nesifo samathumbu esivuvukalayo. "
"Ukwazi ukukhohlisa izingxenye ze-GI nokuhlola imiphumela kungase kuguqule indlela esibheka ngayo izinkinga ze-peristaltic mayelana nokufihla / ukumuncwa," kuqhubeka u-Gatto. "Lawa masu amahle, silindele ukuthi azovumela ukuthi kuthuthukiswe ngokushesha izindlela zethu zokwelapha i-RxAA ukwelapha ukuqunjelwa kanye ne-IBS."
U-Vidyasagar uphinde wethula iphosta ethuluzini elebhu yakhe ethuthukisiwe ukuze kukale kangcono i-peristalsis yamathumbu kanye nokusebenzisana kwengcindezi ye-intraluminal, ukufinyela kwemisipha, kanye nezinguquko zevolumu yoketshezi.
"Ithimba lethu lenze indlela entsha yokuqonda ukusebenza kwe-peristalsis kanye nokusebenza kwe-gut mucosal. Iqhaza le-SAA njengama-RxAA likhombisa isithembiso njengoba sivula izindlela zokuqunjelwa okungapheli, i-IBS nezinye izifo ezihlobene ne-GI,” kusho uDkt. William Denman, Umeluleki Omkhulu Wezokwelapha ku-Etrinsic Bioscience. "Lo msebenzi usaqala kodwa umele igxathu elibalulekile eliya phambili ekuthuthukisweni kwezixazululo zezifo eziningi zokugaya ukudla."
I-Entrinsic Bioscience iyisiqalo se-UF esitholakala e-UF Innovate | Sheshisa e-Sid Martin Biotech e-Alachua. Le nkampani ithuthukisa zonke izinhlobo zemvelo, ezingenayo i-glucose ukuze kufakwe amanzi emitholampilo, impilo yamathumbu kanye nempilo enhle, i-allergies, nokunakekelwa kwesikhumba.
LOKHO ONGAKUTHATHE KULESI SIHLOKO:
- Sadasivan Vidyasagar, founder and chairman of the company’s scientific advisory board, recently shared a tool to better measure peristalsis and the interactions of intraluminal pressure, muscle contraction, and changes in fluid volume at the Experimental Biology 2022 conference held in Philadelphia.
- U-Vidyasagar uphinde wethula iphosta ethuluzini elebhu yakhe ethuthukisiwe ukuze kukale kangcono i-peristalsis yamathumbu kanye nokusebenzisana kwengcindezi ye-intraluminal, ukufinyela kwemisipha, kanye nezinguquko zevolumu yoketshezi.
- “The team’s presentation highlights our ability to better measure gut peristalsis and lays out the path for future treatment regimens that can address opioid-induced chronic constipation as well a non-PEG-based approach to acute constipation and IBS-C.
