Esihlokweni sokubuyekeza sakamuva esishicilelwe ku-Coordination Chemistry Reviews, ithimba lososayensi eliholwa oSolwazi Chang Yeon Lee kanye noGajendra Gupta base-Incheon National University, eKorea, baxoxe ngokuziphendukela kwemvelo kanye nenqubekela phambili yakamuva emkhakheni wama-MOC nama-MOF asekelwe e-BODIPY, gxila emisebenzini engaba khona yenhlanganisela njengezidakamizwa ezilwa nomdlavuza namathuluzi ocwaningo lomdlavuza. I-athikili ichaza izinzuzo ezihlukahlukene zezinhlanganisela nezinye izindlela zokwelapha futhi ikhuluma nezithiyo ezinkulu ekusebenziseni kwazo okusabalele.
Ngakho-ke, yiziphi lezi zinto futhi yini ezenza zibe inhlanganisela enhle? Ama-MOC kanye nama-MOF ayizakhiwo zensimbi ezisebenza njengezinkundla eziguquguqukayo lapho ukusebenza okusha kungethulwa kalula ngokuguqulwa. Zombili zisetshenziswa kabanzi ku-biomedicine futhi zibonise amandla njengama-anticancer agents anokukhetha okuhle. Kodwa-ke, uma i-BODIPY isetshenziswa kuma-MOC noma ama-MOF, izakhiwo zezithombe zenhlanganisela ewumphumela zingashunwa kahle ukuze kuzuzwe imiphumela eyahlukahlukene.
Okokuqala, ama-BODIPY-based complexes ama-photosensitizing agents amahle okwelashwa kwe-photodynamic, lapho umuthi ucushwa ukukhanya ukuze ucekele phansi amaseli okuqondiwe. Uma kuhlanganiswa nama-MOC noma ama-MOF, ukusebenza kahle kwalezi zinkimbinkimbi njengoba izidakamizwa ezilwa nomdlavuza ziyakhula. Okwesibili, ama-BODIPY-based complexes azwela ku-acidity (pH) ye-medium. Ngenxa yokuthi izimila eziyingozi zivame ukuba ne-pH ephansi (i-acidic), lezi zinhlanganisela zingase zenziwe kabusha ukuze ziqondise ngokukhethekile kumaseli anomdlavuza emzimbeni ngokusebenzisa le nqubo. Okokugcina, kodwa ngokuqinisekile okungenani, izici ze-fluorescent zama-MOC nama-MOF zingalungiswa ukuze indawo yazo ngaphakathi kwamaseli ilandelelwe kalula kusetshenziswa amasu e-fluorescence microscopy. "Ukukhululeka okukhulu kwezidakamizwa ezisekelwe ku-BODIPY-based MOC / MOF ngaphakathi kwamangqamuzana omdlavuza alashwe kuzosiza izazi zebhayoloji yamangqamuzana namangqamuzana ukuba ziqonde izindlela zokwenza la ma-molecule ngokumelene nomdlavuza," kuchaza uProf. Lee.
Naphezu kweminye imikhawulo yama-MOC/MOF asuselwa ku-BODIPY, njengokuhlanganiswa okudla isikhathi kanye nokuqonda kwethu okungaphelele ngobuthi bayo, lezi zinhlanganisela zingaba abadlali ababalulekile ekulweni kwethu nomdlavuza. “Ama-MOC kanye nama-MOF aklanywe nge-BODIPY anazo zonke izici ezibalulekile ezidingekayo ukuze ube umuntu ofanelekayo ezidakamizwa ezilwa nomdlavuza,” kuphetha uProf. Gupta. Qiniseka ukuthi uhlale ubhekile la ma-molecule athuthukile nezimangaliso ezingase zilethe emhlabeni wokwelapha umdlavuza kanye nocwaningo.
