Ukusetshenziswa Okusha Komuthi Wokugoma I-Sputnik njenge-Universal Booster

Kunabantu abayizigidi eziyizinkulungwane ezimbili abathole imigomo yamaShayina engasebenzi ezweni nasemhlabeni jikelele. Njengoba i-China isanda kugunyaza ukuxutshwa nokukhuthazwa komdlalo ngemithi yokugoma yasekhaya, umuthi wokugomela i-Sputnik Light waseRussia onesibhamu esisodwa ungaba isikhuthazo salabo abagonywe ngemijovo yamaShayina kwamanye amazwe emhlabeni wonke ukuze baqinise futhi banwebe isivikelo sabo ku-COVID.

Iziphathimandla zase-China zigunyaze ukuxubaniswa kwemithi yokugomela yasekhaya engasasebenzi elwa ne-COVID (ikakhulukazi, i-Sinovac ne-Sinopharm) kanye nokusetshenziswa komuthi wokugoma ohlukile, okubandakanya i-adenoviral-based, njenge-booster shot enikeza esinye isiqinisekiso sokuphumelela kokuhlanganiswa nendlela yokufanisa. ngomuthi wokugoma we-Russian Sputnik V ekudaleni amasosha omzimba aqinile futhi ahlala isikhathi eside, okuhlanganisa ngokumelene nokwahluka kwe-Omicron.

Imithi yokugoma ekhiqizwe izinkampani zaseShayina (i-Sinovac ne-Sinopharm) isetshenziswa kakhulu ngemithamo engaphezu kwezigidigidi ezi-4.7 ehlinzekwa e-China nasemhlabeni jikelele[1]. Ngenkathi uMkhandlu Wombuso WaseShayina ugunyaze ukuxubana nokukhushulwa komdlalo ngemithi yokugoma yasekhaya kuphela[2], umuthi wokugomela i-Sputnik Light onesibhamu esisodwa saseRussia (ingxenye yokuqala ye-Sputnik V) ungaba yisixazululo sokuthuthukisa labo ababegonywe ekuqaleni ngemijovo yamaShayina kwamanye amazwe aseduze. Umhlaba.

I-Sputnik Light isivele ibonise imiphumela enamandla esetshenziswa njenge-booster ezivivinyweni zemiksi nokufanisa, okuhlanganisa nemithi yokugoma engacushiwe. Isibonelo, ucwaningo olwenziwa e-Argentina ngenhlanganisela yokukhanya kwe-Sputnik neminye imithi yokugoma lubonise ukuthi impendulo ye-antibody kanye ne-T-cell etholwe i-Sputnik Light njenge-booster emuthini wokugomela we-Sinopharm ongacushiwe iphakeme ngo-10x uma iqhathaniswa namashothi amabili e-Sinopharm. Ucwaningo luphinde lwaveza ukuthi inhlanganisela ngayinye "yokugoma" ne-Sputnik Light neminye imithi yokugoma efana neModerna, i-AstraZeneca kanye ne-Cansino inikeze i-antibody titer ephakeme ngosuku lwe-14 ngemuva kokunikeza umthamo wesibili uma uqhathaniswa nowangempela we-homologous (umgomo ofanayo nowokuqala kanye umthamo wesibili) izinhlobo zomuthi wokugoma ngamunye. Ukusebenzisa i-Sputnik Light kuzinhlanganisela nayo yonke eminye imithi yokugoma kubonise ukuphepha okuphezulu ngaphandle kwezenzakalo ezimbi kakhulu ezilandela ukugoma kunoma yiziphi izinhlanganisela.      

Indlela yokuthuthukisa ehlukahlukene (“i-vaccine cocktail” isebenzisa i-human adenovirus serotype 26 njengengxenye yokuqala kanye ne-human adenovirus serotype 5 njengengxenye yesibili) eyasungulwa yi-Russian Gamaleya Center iyisisekelo se-Sputnik V, umgomo wokuqala obhalisiwe emhlabeni wokugomela i-coronavirus. Le ndlela ibonakale iphumelele ekudaleni ukuzivikela okunde futhi okuhlala isikhathi eside ngokumelene ne-coronavirus njengoba kuboniswa idatha yomhlaba wangempela evela eHungary, San Marino, Argentina, Serbia, Bahrain, Mexico, UAE nakwamanye amazwe.

Kuze kube manje i-Sputnik Light ivunyelwe emazweni angaphezu kwama-30 anenani labantu abangaphezu kwezigidigidi ezingu-2.5 kanye ne-Sputnik V - emazweni angu-71 anabantu abangaphezu kwezigidigidi ezi-4.

I-Sputnik V idala impendulo eqinile nehlala isikhathi eside yamasosha omzimba ngokumelene ne-COVID (kuhlanganise nokwahluka kwe-Omicron) kuneminye imithi yokugoma eminingi, eqiniswa nakakhulu i-Sputnik Light booster. Ucwaningo lokuqhathanisa oluyingqayizivele[3] olwenziwa eLazzaro Spallanzani National Institute for Infectious Diseases e-Italy yithimba lososayensi base-Italy abangu-12 nabangu-9 baseRussia eliholwa uFrancesco Vaia, uMqondisi we-Spallanzani Institute kanye no-Alexander Gintsburg, uMqondisi weGamaleya Centre ubonise lokho. Umuthi wokugomela i-Sputnik V ubonisa okuphindwe izikhathi ezingaphezu kwezingu-2 kwamazinga aphakeme amasosha omzimba anciphisa igciwane ku-Omicron (B.1.1.529) okuhlukile kunemithamo emi-2 yomgomo we-Pfizer (izikhathi ezingu-2.1 ngaphezulu kwengqikithi kanye nezikhathi ezingu-2.6 ngaphezu kwezinyanga ezi-3 ngemva kokugoma).

Ucwaningo lwenziwe ngezimo ezilinganayo zaselabhorethri kumasampula esera aqhathanisekayo avela kubantu abagonywe nge-Sputnik V ne-Pfizer enezinga elifanayo lamasosha omzimba e-IgG kanye nomsebenzi wokunciphisa igciwane (VNA) ngokumelene nokuhluka kwe-Wuhan. I-Sputnik V ibonise ukuncishiswa okuncane kakhulu (izikhathi ezingu-2.6) komsebenzi wokunciphisa igciwane ngokumelene ne-Omicron uma kuqhathaniswa nereferensi ehlukile ye-Wuhan kunomuthi wokugomela i-Pfizer (ukunciphisa okuphindwe ka-8.1 kwe-Sputnik V ngokungafani nokwehliswa okuphindwe ka-21.4 komgomo we-Pfizer).