Ukwelashwa Kwe-Cancer Pancreatic: Ukukhuthaza Imiphumela Yokusinda

Ukusinda okumaphakathi yizinyanga eziyi-12.7, ukusinda kwe-immune progression-free survival (iPFS) yizinyanga ezingu-7.2, kanti izinga lokusinda lonyaka owodwa lingu-1%. Ngesikhathi sokuhlaziya, iziguli eziyi-55 bezisaphila kanti iziguli ezimbili bezelashwayo. Amazinga okuphepha nezimpendulo afana nesibuyekezo sangaphambilini sangoMeyi 12.

I-interleukin-1 receptor accessory protein (IL1RAP) -i-antibody ebophayo i-nadunolimab iwuhlelo oluholayo lwe-Cantargia futhi luphenywa ezinhlolweni eziningi zemitholampilo ezihlola izinhlobo zemithi yokwelapha eyinhlanganisela ehlukahlukene ezinhlotsheni ezahlukene zomdlavuza, kanti i-PDAC iyona efundwa kabanzi. Kuze kube manje, ngaphezu kweziguli ze-PDAC ze-70 zithole ukwelashwa nge-nadunolimab kuhlanganiswe ne-gemcitabine kanye ne-nab-paclitaxel esigabeni I/IIa socwaningo lomtholampilo lwe-CANFOUR. Isibuyekezo esibikwe namuhla sisekelwe eqenjini lokuqala leziguli ezingama-33 ezihlolwe ukusebenza ngempumelelo.

Ekuhlaziyweni kwesikhashana okubuyekeziwe, okunesikhathi sokulandelela eside kunokufundwa kwangaphambilini okuholela ekuhlaziyweni okuqine kakhulu, ukusinda okumaphakathi yizinyanga eziyi-12.7 kanye nezinga lokusinda lonyaka ongu-1 ngu-55%. I-iPFS emaphakathi yizinyanga eziyi-7.2 ne-iPFS yezinyanga eziyisi-6 ka-56%. Uma kuqhathaniswa, idatha yomlando ekwelashweni komugqa wokuqala weziguli ze-PDAC ezine-gemcitabine ne-nab-paclitaxel ibonisa ukusinda okumaphakathi kwezinyanga ezingu-8.5 ngenani lokusinda lonyaka ongu-1 lama-35%, kanye ne-PFS emaphakathi yezinyanga ezingu-5.5 ene-PFS yezinyanga ezingu-6 ye-44% 1. Ngesikhathi kuhlaziywa iziguli ezimbili bezisathola ukwelashwa kanti ezingu-12 bezisaphila. Kuyathakazelisa ukuthi iziguli eziyisi-6 (18%) ocwaningweni zithole ukwelashwa isikhathi esingaphezu konyaka owodwa.

Iphrofayili yokuphepha empeleni ayishintshile kusukela ekubuyekezweni kwangaphambilini kanti izehlakalo ze-neutropenia kanye ne-febrile neutropenia ziphezulu kunalokho obekulindelwe ekwelapheni ngamakhemikhali kuphela. Ngokuphawulekayo, i-febrile neutropenia ibonakala kuphela phakathi nomjikelezo wokuqala wokwelapha futhi ingavinjelwa kakhulu ngokwelashwa kwe-prophylactic nge-granulocyte growth factor G-CSF. Kuyathakazelisa ukuthi azikho izimo ze-neuropathy ezinzima (ibanga lesi-3 noma ngaphezulu), umphumela ovamile ohlangothini lwe-gemcitabine kanye ne-nab-paclitaxel, eziye zabonwa.

Ngaphezu kwalokho, iziguli ezengeziwe ze-PDAC ezingama-40 ziyaphenywa esandisweni sohlolo lwe-CANFOUR. Imiphumela evela kule ngxenye yocwaningo kulindeleke ukuthi ivuthwe ukuze yethulwe ngesikhathi se-H1 2022. I-Cantargia njengamanje ilungiselela uhlolo olungahleliwe futhi olungase lube semqoka kumugqa wokuqala womdlavuza we-pancreatic. Idizayini nezikhathi zizodalulwa uma izingxoxo zokuzilungiselela neziphathimandla ezinkulu zokulawula seziqediwe.