I-Entrinsic Bioscience kanye nelayisensi yayo i-Nuvara Therapeutics bamemezele ukuthi sebesondele ekusebenziseni ukwakheka kwe-RxAA njengendlela yokwelapha iziguli ezinezinguquko ze-Cystic Fibrosis Class I. Umcwaningi waseNyuvesi yaseFlorida uDkt. Sadasivan Vidyasagar, umsunguli nosihlalo webhodi labaluleki besayensi yenkampani, muva nje wabelane ngenye indlela yokubuyisela ukukhishwa kwe-anion yomoya engqungqutheleni ye-Experimental Biology 2022 eyayise-Philadelphia.
U-Vidyasagar nethimba lakhe, elihlanganisa abacwaningi abavela ku-UF kanye ne-Entrinsic Bioscience, babonise ukuthi ifomula ye-Nuvara ye-VS-009 ingaba yinzuzo ezigulini ezinezinguquko ze-Cystic Fibrosis Class I kanye nezinguquko ze-Class II kanye ne-III. Ukwelashwa kungasetshenziswa yedwa noma kuhlanganiswe nezinye izindlela zokwelapha ukuthuthukisa ukukhiqizwa kwe-chloride.
U-Stephen J. Gatto, uSihlalo Omkhulu we-Nuvara Therapeutics, uhalalisele u-Astrid Grosche kanye nalo lonke ithimba likaDkt. Vidyasagar ngokuqhubeka nokuzibophezela ekuqhubekiseni phambili izindlela ezintsha zokuhlola ukusebenza kwe-epithelial yokuphefumula.
"Ngifuna ukubonga u-Astrid, uDkt. Vidyasagar kanye nalo lonke iqembu lakhe ngokuzibophezela kwabo ngokungakhathali ukuxazulula izinguquko ze-Class I ku-Cystic Fibrosis, ukuguqulwa okungathinta kufika ku-18% wabantu be-CF," kusho uStephen J. Gatto.
"Lezi zifinyezo ezimbili zibonisa ukuthi ukukhwabanisa kwe-ion-channel kungenzeka ku-epithelium yokuphefumula kusetshenziswa ukwakheka okuhambisanayo kwama-amino acid," kuqhubeka uGatto. “Ukungasebenzi kahle kwe-ion-channel kuwumgogodla wezifo eziningi, njenge-CF nezifo lapho ukwanda kokukhiqizwa kwamafinyila, okuhlanganisa isifuba somoya kanye neCOPD. Lezi zindlela/ukwelashwa kuzosivumela ukuthi silungise ukungena kwama-ion namanzi emgwaqeni womoya ezingeni lamaselula nemiphumela emibi emincane.
“Usenomsebenzi okusamele wenziwe, kodwa leli thuba liyajabulisa futhi lingamela impumelelo ekulawulweni kwe-channelopathies nezifo ezihlobene nakho,” kusho uGatto.
U-Vidyasagar uphinde wethula iphosta ethuluzini elebhu yakhe ethuthukisiwe ukuze kukale kangcono i-peristalsis yamathumbu kanye nokusebenzisana kwengcindezi ye-intraluminal, ukufinyela kwemisipha, kanye nezinguquko zevolumu yoketshezi.
"Lezi zifinyezo ezimbili zihlukile ngoba zibonisa ikhono lokuguqula amaprotheni e-epithelial transmembrane (eTMPs) ngokwakhiwa okukhethiwe kwe-amino SAA (RxAAs)," kusho uDkt. William Denman, Umeluleki Omkhulu Wezokwelapha ku-Nuvara Therapeutics. "Lokhu kuvula umnyango wokwelashwa okuphumelelayo, okungenabuthi ezingeni eliyisisekelo lamaselula, kungakhathalekile i-etiology."
UDkt. Denman uqhube wathi, “Ukwelashwa kwesikhathi esizayo manje kungase kunqunywe futhi kwenziwe ngendlela efanele umgudu ngamunye kanye nesifo - umuthi womuntu wangempela. Kudingeka umsebenzi owengeziwe, kodwa lokhu kungase kuvumele ezinye izindlela zokwelapha ezingeni lamaselula kuzo zonke izinhlobo zezifo ezinemiphumela engemihle emincane.”
I-Entrinsic Bioscience iyisiqalo se-UF esitholakala e-UF Innovate | Sheshisa e-Sid Martin Biotech e-Alachua. Le nkampani ithuthukisa zonke izinhlobo zemvelo, ezingenayo i-glucose ukuze kufakwe amanzi emitholampilo, impilo yamathumbu kanye nempilo enhle, i-allergies, nokunakekelwa kwesikhumba.
LOKHO ONGAKUTHATHE KULESI SIHLOKO:
- Vidyasagar and the rest of his team for their tireless commitment to solve for Class I mutations in Cystic Fibrosis, a mutation which can affect up to 18% of CF population,”.
- “There is still work to be done, but the opportunity is truly exciting and could represent a breakthrough in the management of channelopathies and related diseases,”.
- U-Vidyasagar uphinde wethula iphosta ethuluzini elebhu yakhe ethuthukisiwe ukuze kukale kangcono i-peristalsis yamathumbu kanye nokusebenzisana kwengcindezi ye-intraluminal, ukufinyela kwemisipha, kanye nezinguquko zevolumu yoketshezi.
