“Ithimba le-SNIPR BIOME lijabule ngalesi sigameko esibalulekile, futhi sibheke ngabomvu ukuqalisa ukuhlolwa komtholampilo e-US kamuva kulo nyaka, ukuhlola ubuchwepheshe bethu be-CRISPR obuhlukile. I-SNIPR001 iyimpahla yethu ethuthuke kakhulu, futhi siyaziqhenya ngomzamo weqembu osilethe lapha” kusho uDkt. Christian Grøndahl, Umsunguli kanye noMphathi Omkhulu.

Ukuhlolwa komtholampilo kungavula indlela yohlobo olusha lokwelapha ngokunemba oluqondiswe ngokukhethekile ku-E. coli ezigulini ezinomdlavuza ezine-hematological malignancies - okuwumdlavuza othinta igazi, umnkantsha, nama-lymph nodes. Lezi ziguli zisengozini eyengeziwe yokutheleleka ngegazi elisongela ukuphila ngenxa yalesi sifo, ekwelapheni ngamakhemikhali futhi, okubalulekile, nokudluliselwa kwe-pathogen kusuka emathunjini, lapho i-E. coli ingomunye wabadlali ababaluleke kakhulu ekubangeleni izifo.

I-SNIPR001 ihlose ukukhomba amabhaktheriya e-E. coli emathunjini, futhi ngaleyo ndlela ivimbele ukudluliselwa kwalawa magciwane egazini, kuyilapho ishiya amagciwane e-commensal ku-microbiome yesiguli engathinteki. Indlela nge-SNIPR001 isebenzisa uhlelo olusha lobuchwepheshe bethu be-CRISPR/Cas ukuze kuqedwe ngokukhetha amagciwane e-E. coli emathunjini. Le ndlela enembayo ingase iguqule indlela izifo ze-E. coli ezivinjelwa futhi zelashwe ngayo, ikakhulukazi ewodini lomdlavuza.

Namuhla, azikho izindlela zokwelapha ezigunyaziwe zokwelashwa kwe-prophylactic kulesi silungiselelo.

"Ngokusekelwe kudatha yethu yangaphambi komtholampilo nge-SNIPR001 sikholelwa ukuthi ubuchwepheshe bethu bunamandla amakhulu ekuklameni imithi yakusasa esekelwe ku-CRISPR ngokumelene nezifo ezisongela ukuphila kanye nokulinganisa izifo ezihlobene ne-microbiome" kusho uDkt. Milan Zdravkovic, Isikhulu Esiyinhloko Sezokwelapha kanye neNhloko. we-R&D kwa-SNIPR Biome. “Ngokwenyuka kokumelana nokulwa namagciwane kunesidingo esiphuthumayo sokuthi abantu abasha bezidakamizwa baphathe amagciwane athathelwanayo, njenge-E. coli, futhi sibonga ukubambisana nenhlangano engenzi nzuzo, i-CARB-X ku-SNIPR001”.

I-SNIPR001 ingeyokuqala kwabaningi abangase bangenele ukhetho lwezokwelapha, njengoba kuqokonyiswe uDkt. Christian Grøndahl: “Sakha ipayipi eliqinile lempahla ye-CRISPR enoveli futhi sinentshisekelo engaphezu kwentshiseko yethu ezifweni ezithathelwanayo, ukusebenzisana ne-MD Anderson Cancer Center on immuno-oncology, kanye neNovo Nordisk ekusebenziseni ubuchwepheshe bokushintshwa kofuzo ku-microbiome. Sijabule ukuhlola amandla aphelele obuchwepheshe bethu be-CRISPR esikhathini esizayo”.

LOKHO ONGAKUTHATHE KULESI SIHLOKO:

“We are building a strong pipeline of novel CRISPR assets and have beyond our interest in infectious diseases, collaborations with the MD Anderson Cancer Center on immuno-oncology, and with Novo Nordisk on applying gene-modulation technologies on the microbiome.
coli bacteria in the gut, and thereby prevent the translocation of these bacteria to the bloodstream, while leaving the commensal bacteria in the patient’s microbiome unaffected.
These patients are at increased risk of life-threatening bloodstream infections due to the disease, to chemotherapy treatment and, importantly, to pathogen translocation from the gut, in which E.